Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | PARP1 | P09874 | 3/20 | 0.46 |
| ▸ | CHEK2 | O96017 | 3/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | DHODH | Q02127 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | PIN1 | Q13526 | 3/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.42 |
| ▸ | CASP1 | P29466 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | MAP2K3 | P46734 | 1/20 | 0.41 |
| ▸ | IKBKB | O14920 | 2/20 | 0.41 |
| ▸ | CHUK | O15111 | 1/20 | 0.41 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.40 |
| ▸ | CDC7 | O00311 | 1/20 | 0.40 |
| ▸ | PLK4 | O00444 | 1/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.40 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1080850 | 0.87 | PIN1 (0.47) | ALDH1A1CYP1A2DHODHKDM4EPIN1 | |
| Hydrochloric Acid SCHEMBL6861539 | 0.85 | PIN1 (0.46) | ALDH1A1CYP1A2DHODHKDM4EPIN1 | |
| SCHEMBL811735 | 0.85 | MAPT (0.46) | ALDH1A1CYP1A2KDM4EPIN1MAPK1 | |
| SCHEMBL30014280 | 0.84 | CCNC (0.51) | PARP1CHEK2MAP2K3CDC7PLK4 | |
| SCHEMBL6861535 | 0.84 | PIN1 (0.41) | ALDH1A1PARP1CYP1A2DHODHPIN1 | |
| SCHEMBL7231545 | 0.84 | PRSS1 (0.44) | ALDH1A1PARP1CYP1A2KDM4E | |
| SCHEMBL3735844 | 0.84 | DCUN1D1 (0.39) | ALDH1A1PARP1CHEK2CYP1A2KDM4E | |
| SCHEMBL19734173 | 0.83 | MEN1 (0.47) | ALDH1A1CYP1A2KDM4EPIN1CDC7 | |
| Propionamide SCHEMBL27851687 | 0.82 | KDM4E (0.43) | ALDH1A1PARP1CHEK2CYP1A2KDM4E | |
| SCHEMBL1078329 | 0.82 | CHEK2 (0.48) | ALDH1A1PARP1CHEK2DHODHIKBKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011005052-A2 | NOVEL ARYLPIPERAZINE-CONTAINING IMIDAZOLE 4-CARBOXAMIDE DERIVATIVES AND PHARMACEUTICAL COMPOSITION COMPRISING SAME | GREEN GROSS CORPORATION (KR) | 2011-01-13 | — | — | WO | claimed |
| US-20050256167-A1 | Preparation and use of imidazole derivatives for treatment of obesity | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-11-17 | — | — | US | disclosed |
| US-6960601-B2 | Preparation and use of imidazole derivatives for treatment of obesity | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-11-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050256167-A1 | Preparation and use of imidazole derivatives for treatment of obesity | GPR119, GIPR, PGC | ALDH1A1 2202/4885PARP1 4121/4885CHEK2 2365/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.