SCHEMBL13728735

SCHEMBL13728735

Nc1ccc(/C=C\Cc2ccc(-c3nccs3)cc2)cn1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LOXL2 Q9Y4K0 1/20 0.50
ADRB2 P07550 3/20 0.43
PDPK1 O15530 1/20 0.41
CYP2A6 P11509 1/20 0.37
ESR1 P03372 1/20 0.36
HDAC2 Q92769 2/20 0.35
HDAC3 O15379 1/20 0.35
HDAC4 P56524 1/20 0.35
HDAC1 Q13547 1/20 0.35
HDAC7 Q8WUI4 1/20 0.35
HDAC10 Q969S8 1/20 0.35
HDAC11 Q96DB2 1/20 0.35
HDAC8 Q9BY41 1/20 0.35
HDAC6 Q9UBN7 1/20 0.35
HDAC9 Q9UKV0 1/20 0.35
HDAC5 Q9UQL6 1/20 0.35
CHEK2 O96017 1/20 0.35
SLC6A4 P31645 1/20 0.34
SLC6A3 Q01959 1/20 0.34
HSP90AA1 P07900 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4021798 0.76 LOXL2 (0.55) LOXL2ADRB2PDPK1CYP2A6HDAC2
SCHEMBL13727384 0.76 EPHX2 (0.37) KDM4EGABRPGABRDGABRA1GABRB1
SCHEMBL1104627 0.75 MAOB (0.47) HDAC1GABRPGABRDGABRA1GABRB1
SCHEMBL27613042 0.74 LOXL2 (0.57) LOXL2ADRB2PDPK1CYP2A6ESR1
SCHEMBL27803019 0.74 LOXL2 (0.66) LOXL2ADRB2PDPK1CYP2A6ESR1
SCHEMBL6878120 0.73 LOXL2 (0.51) LOXL2ADRB2PDPK1CYP2A6ESR1
SCHEMBL6878128 0.73 LOXL2 (0.51) LOXL2ADRB2PDPK1CYP2A6ESR1
SCHEMBL6850509 0.72 LOXL2 (0.62) LOXL2ADRB2PDPK1CYP2A6ESR1
SCHEMBL30278534 0.70 ADRB2 (0.48) LOXL2ADRB2PDPK1CYP2A6ESR1
SCHEMBL15793096 0.69 LOXL2 (0.44) LOXL2ADRB2PDPK1CYP2A6ESR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2704701-A1 COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES Synta Pharmaceuticals Corp. (US) 2014-03-12 EP disclosed
WO-2012151355-A1 COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES SYNTA PHARMACEUTICALS CORP. (US) 2012-11-08 WO disclosed