Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | PRTN3 | P24158 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | ELANE | P08246 | 2/20 | 0.46 |
| ▸ | TGM2 | P21980 | 1/20 | 0.46 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.45 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | KLK1 | P06870 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13725383 | 0.81 | ELANE (0.51) | HTTPRTN3SMN1; SMN2LMNAELANE | |
| SCHEMBL14002292 | 0.81 | HTT (0.60) | HTTPRTN3SMN1; SMN2LMNAELANE | |
| SCHEMBL4586916 | 0.81 | HTT (0.60) | HTTPRTN3SMN1; SMN2LMNAELANE | |
| SCHEMBL13729442 | 0.80 | BTN3A1 (0.55) | HTTPRTN3SMN1; SMN2LMNAELANE | |
| SCHEMBL13729445 | 0.79 | PRTN3 (0.49) | HTTPRTN3SMN1; SMN2LMNAELANE | |
| SCHEMBL14269142 | 0.78 | BTN3A1 (0.56) | HTTPRTN3ELANEL3MBTL1MAPT | |
| SCHEMBL14002286 | 0.76 | PRTN3 (0.49) | HTTPRTN3SMN1; SMN2LMNAELANE | |
| SCHEMBL26962307 | 0.75 | HTT (0.63) | HTTSMN1; SMN2LMNATGM2KEAP1 | |
| SCHEMBL13538361 | 0.75 | LMNA (0.58) | HTTPRTN3SMN1; SMN2LMNAELANE | |
| SCHEMBL3362572 | 0.75 | HTT (0.67) | HTTSMN1; SMN2LMNATGM2KEAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012150866-A1 | PHOSPHORIBOSYLTRANSFERASE INHIBITORS AND USES THEREOF | INDUSTRIAL RESEARCH LIMITED (NZ) | 2012-11-08 | — | — | WO | disclosed |