Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.38 |
| ▸ | CACNA1F | O60840 | 2/20 | 0.37 |
| ▸ | CACNA1D | Q01668 | 2/20 | 0.37 |
| ▸ | CACNA1S | Q13698 | 2/20 | 0.37 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | CES1 | P23141 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | SLC26A6 | Q9BXS9 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8544450 | 0.87 | HTT (0.47) | HTTCYP1A2ALDH1A1CACNA1FCACNA1D | |
| SCHEMBL15599072 | 0.82 | HTT (0.43) | HTTCYP1A2ALDH1A1CACNA1FCACNA1D | |
| SCHEMBL7400591 | 0.80 | HTT (0.52) | HTTCYP1A2ALDH1A1CACNA1FCACNA1D | |
| SCHEMBL9461101 | 0.77 | HTT (0.50) | HTTCYP1A2ALDH1A1CACNA1FCACNA1D | |
| SCHEMBL15284739 | 0.77 | HTT (0.50) | HTTCYP1A2ALDH1A1CACNA1FCACNA1D | |
| SCHEMBL3559987 | 0.76 | HTT (0.49) | HTTCYP1A2ALDH1A1CACNA1FCACNA1D | |
| SCHEMBL25677447 | 0.76 | HTT (0.40) | HTTCYP1A2ALDH1A1CACNA1FCACNA1D | |
| SCHEMBL23367206 | 0.75 | MMP2 (0.49) | HTTALDH1A1CES1HPGDKDM4E | |
| Hydrochloric Acid SCHEMBL4493041 | 0.75 | HTT (0.48) | HTTCYP1A2ALDH1A1CACNA1FCACNA1D | |
| SCHEMBL12410861 | 0.75 | HTT (0.48) | HTTCYP1A2ALDH1A1CACNA1FCACNA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2699561-B1 | ANDROGEN RECEPTOR MODULATING CARBOXAMIDES | ORION CORP (FI) | 2015-06-03 | — | — | EP | disclosed |
| US-8921378-B2 | Androgen receptor modulating carboxamides | ORION CORPORATION (FI) | 2014-12-30 | — | — | US | disclosed |
| EP-2699561-A1 | ANDROGEN RECEPTOR MODULATING CARBOXAMIDES | Orion Corporation (FI) | 2014-02-26 | — | — | EP | disclosed |
| WO-2012143599-A1 | ANDROGEN RECEPTOR MODULATING CARBOXAMIDES | ORION CORPORATION (FI) | 2012-10-26 | — | — | WO | disclosed |