Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | CES1 | P23141 | 1/20 | 0.33 |
| ▸ | CACNA1F | O60840 | 2/20 | 0.33 |
| ▸ | CACNA1D | Q01668 | 2/20 | 0.33 |
| ▸ | CACNA1S | Q13698 | 2/20 | 0.33 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | SLC26A6 | Q9BXS9 | 3/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8544450 | 0.82 | HTT (0.47) | HTTCYP1A2ALDH1A1CES1CACNA1F | |
| SCHEMBL13733197 | 0.82 | HTT (0.49) | HTTCYP1A2ALDH1A1CES1CACNA1F | |
| SCHEMBL15599074 | 0.78 | GAA (0.40) | ALDH1A1L3MBTL1KDM4EGAASMN1; SMN2 | |
| SCHEMBL7400591 | 0.73 | HTT (0.52) | HTTCYP1A2ALDH1A1CACNA1FCACNA1D | |
| SCHEMBL25677447 | 0.72 | HTT (0.40) | HTTCYP1A2ALDH1A1CACNA1FCACNA1D | |
| SCHEMBL9461101 | 0.70 | HTT (0.50) | HTTCYP1A2ALDH1A1CACNA1FCACNA1D | |
| SCHEMBL15284739 | 0.70 | HTT (0.50) | HTTCYP1A2ALDH1A1CACNA1FCACNA1D | |
| SCHEMBL28416827 | 0.70 | CYP1A2 (0.38) | HTTCYP1A2ALDH1A1CACNA1FCACNA1D | |
| SCHEMBL3559987 | 0.69 | HTT (0.49) | HTTCYP1A2ALDH1A1CACNA1FCACNA1D | |
| SCHEMBL23367206 | 0.69 | MMP2 (0.49) | HTTALDH1A1CES1SLC26A6L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014031936-A2 | HETEROCYCLIC MODULATORS OF HIF ACTIVITY FOR TREATMENT OF DISEASE | JONES PHILIP (US) | 2014-02-27 | — | — | WO | disclosed |