SCHEMBL13733737

SCHEMBL13733737

Cc1ccc(-n2nccn2)c(C(=O)N2CCCCCN2)c1

nearest known ligand 0.49

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
HCRTR2 O43614 20/20 0.49
HCRTR1 O43613 19/20 0.49
CYP3A4 P08684 2/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL30644096 0.94 HCRTR2 (0.50) HCRTR2HCRTR1CYP3A4
Hydrochloric Acid SCHEMBL26643055 0.94 HCRTR2 (0.50) HCRTR2HCRTR1CYP3A4
SCHEMBL17539262 0.82 HCRTR2 (0.64) HCRTR2HCRTR1
SCHEMBL2358754 0.82 HCRTR2 (0.64) HCRTR2HCRTR1
SCHEMBL30644100 0.81 HCRTR1 (0.43) HCRTR2HCRTR1CYP3A4
SCHEMBL17501812 0.81 HCRTR2 (0.65) HCRTR2HCRTR1
Hydrochloric Acid SCHEMBL26643081 0.80 HCRTR1 (0.48) HCRTR2HCRTR1
SCHEMBL23018148 0.79 HCRTR2 (0.58) HCRTR2HCRTR1CYP3A4
SCHEMBL8217802 0.74 HCRTR2 (0.58) HCRTR2HCRTR1CYP3A4
SCHEMBL2904344 0.74 HCRTR2 (0.58) HCRTR2HCRTR1CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3177616-A1 NOVEL ROUTES OF SYNTHESIS FOR THE PREPARATION OF SUVOREXANT Sandoz AG (CH) 2017-06-14 EP disclosed
WO-2016020405-A1 NOVEL ROUTES OF SYNTHESIS FOR THE PREPARATION OF SUVOREXANT SANDOZ AG (CH) 2016-02-11 WO disclosed
EP-2680697-A1 PROCESS FOR THE PREPARATION OF AN OREXIN RECEPTOR ANTAGONIST Merck Sharp & Dohme Corp. (US) 2014-01-08 EP disclosed
WO-2012148553-A1 PROCESS FOR THE PREPARATION OF AN OREXIN RECEPTOR ANTAGONIST MERCK SHARP & DOHME CORP. (US) 2012-11-01 WO disclosed