Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 10/20 | 0.53 |
| ▸ | JAK2 | O60674 | 9/20 | 0.53 |
| ▸ | JAK3 | P52333 | 6/20 | 0.53 |
| ▸ | TYK2 | P29597 | 6/20 | 0.53 |
| ▸ | ALK | Q9UM73 | 5/20 | 0.51 |
| ▸ | CDK19 | Q9BWU1 | 4/20 | 0.51 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.49 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.44 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.44 |
| ▸ | TPX2 | Q9ULW0 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29979953 | 0.80 | JAK1 (0.50) | JAK1JAK2JAK3TYK2ALK | |
| SCHEMBL672922 | 0.79 | JAK1 (0.52) | JAK1JAK2JAK3TYK2ALK | |
| SCHEMBL22159389 | 0.78 | APP (0.50) | JAK1JAK2JAK3TYK2ALK | |
| SCHEMBL14801269 | 0.77 | PTK2 (0.56) | JAK1JAK2JAK3ALKCDK19 | |
| SCHEMBL14801718 | 0.77 | PTK2 (0.56) | JAK1JAK2JAK3ALKCDK19 | |
| SCHEMBL19027053 | 0.76 | PTK2 (0.64) | JAK3ALKCDK19LRRK2PTK2 | |
| SCHEMBL15380926 | 0.75 | CDK2 (0.54) | JAK2JAK3TYK2LRRK2PTK2 | |
| SCHEMBL29813554 | 0.75 | EGFR (0.62) | ALKEGFRAURKA | |
| SCHEMBL17112501 | 0.74 | EGFR (0.48) | PTK2EGFR | |
| SCHEMBL6882453 | 0.73 | AURKA (0.55) | MAPK1AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012143320-A1 | (7H-PYRROLO[2,3-D]PYRIMIDIN-2-YL)AMINE COMPOUNDS AS JAK3 INHIBITORS | CELLZOME LIMITED (GB) | 2012-10-26 | — | — | WO | disclosed |