Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 2/20 | 0.55 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | SYK | P43405 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | CDK4 | P11802 | 1/20 | 0.45 |
| ▸ | CCND1 | P24385 | 1/20 | 0.45 |
| ▸ | CCND2 | P30279 | 1/20 | 0.45 |
| ▸ | CCND3 | P30281 | 1/20 | 0.45 |
| ▸ | CDC7 | O00311 | 2/20 | 0.45 |
| ▸ | CDK1 | P06493 | 1/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15380926 | 0.83 | CDK2 (0.54) | AURKANPC1RAB9AMAPK1MAPT | |
| SCHEMBL25016924 | 0.79 | RPS6KA3 (0.47) | AURKASYKULK1 | |
| SCHEMBL14287382 | 0.78 | AURKA (0.44) | AURKARAB9AMAPK1MEN1MAPT | |
| SCHEMBL17604427 | 0.78 | SYK (0.58) | NPC1RAB9AMAPTKMT2ASYK | |
| SCHEMBL3429733 | 0.77 | SYK (0.59) | AURKANPC1RAB9AMAPTKMT2A | |
| SCHEMBL878920 | 0.75 | ULK1 (0.52) | AURKANPC1RAB9AMAPK1CDC7 | |
| SCHEMBL29277198 | 0.75 | SYK (0.60) | AURKAMAPK1MAPTSYKCDK4 | |
| SCHEMBL29813554 | 0.74 | EGFR (0.62) | AURKACDK4CCND1CCND2CCND3 | |
| SCHEMBL17065188 | 0.73 | MAPK1 (0.51) | NPC1RAB9AMAPK1MEN1LMNA | |
| SCHEMBL12127741 | 0.73 | APP (0.56) | NPC1RAB9AMAPK1MEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0832091-B1 | C-4' MODIFIED ADENOSINE KINASE INHIBITORS | GENSIA SICOR INC (US) | 2004-01-14 | — | — | EP | disclosed |