Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | SMPD3 | Q9NY59 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
| ▸ | BTK | Q06187 | 1/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.39 |
| ▸ | CDC42BPB | Q9Y5S2 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | PPARA | Q07869 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | S100A4 | P26447 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15873401 | 0.88 | MEN1 (0.40) | MAPTALDH1A1KMT2AMEN1POLB | |
| SCHEMBL15873402 | 0.88 | MEN1 (0.40) | MAPTALDH1A1KMT2AMEN1POLB | |
| SCHEMBL26632137 | 0.83 | MAPT (0.39) | MAPTALDH1A1KMT2AMEN1TDP1 | |
| SCHEMBL4443908 | 0.81 | MAPT (0.46) | MAPTALDH1A1KMT2AMEN1GAA | |
| SCHEMBL15873243 | 0.81 | MAPT (0.46) | MAPTALDH1A1KMT2AMEN1GAA | |
| SCHEMBL15873245 | 0.81 | MAPT (0.46) | MAPTALDH1A1KMT2AMEN1GAA | |
| SCHEMBL4444188 | 0.81 | MAPT (0.46) | MAPTALDH1A1KMT2AMEN1GAA | |
| SCHEMBL13736923 | 0.79 | ALDH1A1 (0.46) | MAPTALDH1A1KMT2AMEN1POLB | |
| SCHEMBL15913876 | 0.79 | ALDH1A1 (0.46) | MAPTALDH1A1KMT2AMEN1POLB | |
| SCHEMBL13736896 | 0.78 | ALDH1A1 (0.56) | MAPTALDH1A1KMT2AMEN1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2702063-A1 | BICYCLIC PYRIDAZINE COMPOUNDS AS PIM INHIBITORS | Amgen Inc. (US) | 2014-03-05 | — | — | EP | disclosed |
| WO-2012148775-A1 | BICYCLIC PYRIDAZINE COMPOUNDS AS PIM INHIBITORS | AMGEN INC. (US) | 2012-11-01 | — | — | WO | disclosed |