Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | BTK | Q06187 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 9/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15873401 | 1.00 | MEN1 (0.40) | MEN1KMT2APOLBMAPTALDH1A1 | |
| SCHEMBL13735271 | 0.88 | MAPT (0.42) | MEN1KMT2APOLBMAPTALDH1A1 | |
| SCHEMBL15887100 | 0.86 | BTK (0.54) | LCKJAK3BTK | |
| SCHEMBL26632154 | 0.83 | CHRM4 (0.41) | MAPTALDH1A1CHRM4LMNA | |
| SCHEMBL4443908 | 0.81 | MAPT (0.46) | MEN1KMT2APOLBMAPTALDH1A1 | |
| SCHEMBL15873245 | 0.81 | MAPT (0.46) | MEN1KMT2APOLBMAPTALDH1A1 | |
| SCHEMBL4444188 | 0.81 | MAPT (0.46) | MEN1KMT2APOLBMAPTALDH1A1 | |
| SCHEMBL15873243 | 0.81 | MAPT (0.46) | MEN1KMT2APOLBMAPTALDH1A1 | |
| SCHEMBL13736923 | 0.78 | ALDH1A1 (0.46) | MEN1KMT2APOLBMAPTALDH1A1 | |
| SCHEMBL15913876 | 0.78 | ALDH1A1 (0.46) | MEN1KMT2APOLBMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2943485-B1 | BICYCLIC AROMATIC CARBOXAMIDE COMPOUNDS USEFUL AS PIM KINASE INHIBITORS | INCYTE HOLDINGS CORP (US) | 2017-09-20 | — | — | EP | disclosed |
| US-9676750-B2 | Bicyclic aromatic carboxamide compounds useful as pim kinase inhibitors | INCYTE CORPORATION (US) | 2017-06-13 | — | — | US | disclosed |
| US-20160137626-A1 | BICYCLIC AROMATIC CARBOXAMIDE COMPOUNDS USEFUL AS PIM KINASE INHIBITORS | INCYTE CORPORATION (US) | 2016-05-19 | — | — | US | disclosed |
| US-9278950-B2 | Bicyclic aromatic carboxamide compounds useful as Pim kinase inhibitors | INCYTE CORPORATION (US) | 2016-03-08 | — | — | US | disclosed |
| US-20140200216-A1 | BICYCLIC AROMATIC CARBOXAMIDE COMPOUNDS USEFUL AS PIM KINASE INHIBITORS | INCYTE CORPORATION (US) | 2014-07-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160137626-A1 | BICYCLIC AROMATIC CARBOXAMIDE COMPOUNDS USEFUL AS PIM KINASE INHIBITORS | PIM1, PIM2, PIM3 | MEN1 4226/4885KMT2A 417/4885POLB 1432/4885 |
| US-20140200216-A1 | BICYCLIC AROMATIC CARBOXAMIDE COMPOUNDS USEFUL AS PIM KINASE INHIBITORS | PIM1, PIM2, PIM3 | MEN1 4226/4885KMT2A 417/4885POLB 1432/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.