Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Norleucine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC1A2 | P43004 | 3/20 | 0.64 |
| ▸ | SLC1A1 | P43005 | 3/20 | 0.64 |
| ▸ | SLC1A3 | P43003 | 2/20 | 0.64 |
| ▸ | GSR | P00390 | 1/20 | 0.58 |
| ▸ | DDAH1 | O94760 | 3/20 | 0.58 |
| ▸ | GRIK1 | P39086 | 3/20 | 0.57 |
| ▸ | GRIK2 | Q13002 | 3/20 | 0.57 |
| ▸ | NOS1 | P29475 | 3/20 | 0.55 |
| ▸ | CA2 | P00918 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | ARG1 | P05089 | 3/20 | 0.52 |
| ▸ | ARG2 | P78540 | 3/20 | 0.52 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | NOS3 | P29474 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | NOS2 | P35228 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | SLC15A1 | P46059 | 1/20 | 0.52 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Norleucine SCHEMBL13736631 | 1.00 | SLC1A2 (0.64) | SLC1A2SLC1A1SLC1A3GSRDDAH1 | |
| Norleucine SCHEMBL8393 | 0.98 | — | — | |
| Norleucine SCHEMBL5051846 | 0.98 | SLC1A2 (0.67) | SLC1A2SLC1A1SLC1A3GSRDDAH1 | |
| Norleucine SCHEMBL26474 | 0.98 | SLC1A2 (0.67) | SLC1A2SLC1A1SLC1A3GSRDDAH1 | |
| Norleucine SCHEMBL198127 | 0.98 | — | — | |
| Norleucine SCHEMBL8392 | 0.98 | — | — | |
| Norleucine SCHEMBL2785913 | 0.98 | SLC1A2 (0.67) | SLC1A2SLC1A1SLC1A3GSRDDAH1 | |
| Norleucine SCHEMBL5497693 | 0.98 | SLC1A2 (0.67) | SLC1A2SLC1A1SLC1A3GSRDDAH1 | |
| Norleucine SCHEMBL5395829 | 0.95 | SLC1A2 (0.64) | SLC1A2SLC1A1SLC1A3GSRDDAH1 | |
| Norleucine SCHEMBL18586277 | 0.95 | SLC1A2 (0.64) | SLC1A2SLC1A1SLC1A3GSRDDAH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116710467-A | Photooxidation reduction protein modification | 罗莎琳德·富兰克林研究所 | 2023-09-05 | — | — | CN | disclosed |
| WO-2012153125-A1 | NOVEL COMPOUNDS AND METHODS FOR USE IN MEDICINE | ASTON UNIVERSITY (GB) | 2012-11-15 | — | — | WO | disclosed |