Norleucine

Norleucine

SCHEMBL5497693

CCCC[C@H](N)C(=O)O.CCCC[C@H](N)C(=O)O

nearest known ligand 0.67

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC1A2 P43004 4/20 0.67
SLC1A1 P43005 4/20 0.67
SLC1A3 P43003 3/20 0.67
GSR P00390 2/20 0.60
DDAH1 O94760 3/20 0.59
GRIK1 P39086 4/20 0.59
GRIK2 Q13002 4/20 0.59
NOS1 P29475 3/20 0.56
CA2 P00918 1/20 0.54
MAPK1 P28482 1/20 0.54
ARG1 P05089 3/20 0.54
ARG2 P78540 3/20 0.54
DPP7 Q9UHL4 1/20 0.53
MEN1 O00255 1/20 0.53
NOS3 P29474 1/20 0.53
CYP2C19 P33261 1/20 0.53
NOS2 P35228 1/20 0.53
KMT2A Q03164 1/20 0.53
SLC15A1 P46059 1/20 0.53
GRM8 O00222 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Norleucine SCHEMBL8393 1.00
Norleucine SCHEMBL8392 1.00
Norleucine SCHEMBL26474 1.00 SLC1A2 (0.67) SLC1A2SLC1A1SLC1A3GSRDDAH1
Norleucine SCHEMBL198127 1.00
Norleucine SCHEMBL5051846 1.00 SLC1A2 (0.67) SLC1A2SLC1A1SLC1A3GSRDDAH1
Norleucine SCHEMBL2785913 1.00 SLC1A2 (0.67) SLC1A2SLC1A1SLC1A3GSRDDAH1
Norleucine SCHEMBL4608461 0.98 SLC1A2 (0.64) SLC1A2SLC1A1SLC1A3GSRDDAH1
Norleucine SCHEMBL13736626 0.98 SLC1A2 (0.64) SLC1A2SLC1A1SLC1A3GSRDDAH1
Norleucine SCHEMBL4163267 0.98 SLC1A2 (0.64) SLC1A2SLC1A1SLC1A3GSRDDAH1
Norleucine SCHEMBL15051960 0.98 SLC1A2 (0.64) SLC1A2SLC1A1SLC1A3GSRDDAH1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114364695-B Antibodies specifically recognizing C5A and uses thereof 舒泰神(北京)生物制药股份有限公司 2024-07-12 CN disclosed
CN-114072145-B Antibodies specifically recognizing pseudomonas PCRV and uses thereof 北京三诺佳邑生物技术有限责任公司 2024-06-11 CN disclosed
CN-118103397-A Antibodies specifically recognizing TNFR2 and uses thereof 舒泰神(加州)生物科技有限公司 2024-05-28 CN disclosed
CN-115023438-B Antibody combinations specifically recognizing pseudomonas PCRV or PSL antigens and bispecific antibodies 北京三诺佳邑生物技术有限责任公司 2024-05-03 CN disclosed
CN-117917436-A Antibody capable of specifically recognizing TRAIL and application thereof 北京三诺佳邑生物技术有限责任公司 2024-04-23 CN disclosed
CN-117917437-A Antibody capable of specifically recognizing TRAIL and application thereof 北京三诺佳邑生物技术有限责任公司 2024-04-23 CN disclosed
WO-2023138521-A1 ANTIBODY SPECIFICALLY RECOGNIZING FASL AND APPLICATION THEREOF 北京三诺佳邑生物技术有限责任公司 2023-07-27 WO disclosed
WO-2023138522-A1 ANTIBODY FOR SPECIFICALLY RECOGNIZING FASL AND USE THEREOF 北京三诺佳邑生物技术有限责任公司 2023-07-27 WO disclosed
WO-2023103789-A1 ANTIBODY SPECIFICALLY RECOGNIZING MASP2 AND USE THEREOF 舒泰神(北京)生物制药股份有限公司 2023-06-15 WO disclosed
WO-2023103788-A1 BISPECIFIC ANTIBODY THAT SPECIFICALLY BINDS TO KLEBSIELLA PNEUMONIAE O2 AND O1 ANTIGENS, AND COMPOSITION 北京三诺佳邑生物技术有限责任公司 2023-06-15 WO disclosed
WO-2005111202-A1 RECOMBINANT ENZYME WITH ALTERED FEEDBACK SENSITIVITY METABOLIC EXPLORER (FR) 2005-11-24 WO disclosed
WO-2005108561-A2 RECOMBINANT ENZYME WITH ALTERED FEEDBACK SENSITIVITY METABOLIC EXPLORER (FR) 2005-11-17 WO disclosed
US-5739101-A ADMINISTERING AN ANTICOAGULANTS GENENTECH, INC. (US) 1998-04-14 US disclosed
US-5698418-A BOVIN SOMATOTROPIN HETEROLOGOUS POLYPEPTIDE EXPRESSED BY A MUTANT MICROORGANISM GROWN ON A CULTURE MEDIUM HAVING LOW AMINO ACID CONCENTRATION, COMPRISING UTILIZING MUTANT MICROORGANISM TO OVERPRODUCE METHIONINE PHARMACIA & UPJOHN COMPANY (US) 1997-12-16 US disclosed
US-5622845-A USING ESCHERICHIA THE UPJOHN COMPANY (US) 1997-04-22 US disclosed
US-5602102-A ADMINSTERING IN TREATMENT OF ORGAN ALLOGRAFT REJECTION BOARD OF REGENTS, THE UNIV. OF TX SYSTEM (US) 1997-02-11 US disclosed
US-5589363-A DNA encoding tissue factor mutants useful for the treatment of myocardial infarction and coagulopathic disorders GENENTECH, INC. (US) 1996-12-31 US disclosed
WO-1993024634-A1 DIPEPTIDYL PEPTIDASE-I, CLONING IT, AND THERAPEUTIC AGENTS CONTAINING INHIBITORS THEREOF BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 1993-12-09 WO disclosed
EP-0401254-A1 METHODS FOR CONTROLLING NORLEUCINE CONTENT IN POLYPEPTIDES. UPJOHN CO (US) 1990-12-12 EP disclosed
WO-1989007651-A2 METHODS FOR CONTROLLING NORLEUCINE CONTENT IN POLYPEPTIDES THE UPJOHN COMPANY (US) 1989-08-24 WO disclosed