Norleucine

Norleucine

SCHEMBL26474

CCCCC(N)C(=O)O.CCCC[C@H](N)C(=O)O

nearest known ligand 0.67

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC1A2 P43004 4/20 0.67
SLC1A1 P43005 4/20 0.67
SLC1A3 P43003 3/20 0.67
GSR P00390 2/20 0.60
DDAH1 O94760 3/20 0.59
GRIK1 P39086 4/20 0.59
GRIK2 Q13002 4/20 0.59
NOS1 P29475 3/20 0.56
CA2 P00918 1/20 0.54
MAPK1 P28482 1/20 0.54
ARG1 P05089 3/20 0.54
ARG2 P78540 3/20 0.54
DPP7 Q9UHL4 1/20 0.53
MEN1 O00255 1/20 0.53
NOS3 P29474 1/20 0.53
CYP2C19 P33261 1/20 0.53
NOS2 P35228 1/20 0.53
KMT2A Q03164 1/20 0.53
SLC15A1 P46059 1/20 0.53
GRM8 O00222 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Norleucine SCHEMBL8393 1.00
Norleucine SCHEMBL8392 1.00
Norleucine SCHEMBL198127 1.00
Norleucine SCHEMBL5051846 1.00 SLC1A2 (0.67) SLC1A2SLC1A1SLC1A3GSRDDAH1
Norleucine SCHEMBL2785913 1.00 SLC1A2 (0.67) SLC1A2SLC1A1SLC1A3GSRDDAH1
Norleucine SCHEMBL5497693 1.00 SLC1A2 (0.67) SLC1A2SLC1A1SLC1A3GSRDDAH1
Norleucine SCHEMBL4608461 0.98 SLC1A2 (0.64) SLC1A2SLC1A1SLC1A3GSRDDAH1
Norleucine SCHEMBL13736626 0.98 SLC1A2 (0.64) SLC1A2SLC1A1SLC1A3GSRDDAH1
Norleucine SCHEMBL4163267 0.98 SLC1A2 (0.64) SLC1A2SLC1A1SLC1A3GSRDDAH1
Norleucine SCHEMBL15051960 0.98 SLC1A2 (0.64) SLC1A2SLC1A1SLC1A3GSRDDAH1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1520073-B1 TRIAZINNYLAMINOSTILBENE DISULPHONIC ACID MIXTURES BASF SE (DE) 2012-01-18 EP claimed
EP-2292837-A1 Triazinylaminostilbene disulphonic acid mixtures BASF SE (DE) 2011-03-09 EP claimed
US-7585333-B2 Fluorescent whitening agent, for whitening synthetic or natural organic materials, especially paper and for the fluorescent whitening and improvement of sun protection factors of textile materials CIBA SPECIALTY CHEMICALS CORPORATION (US) 2009-09-08 US claimed
US-20080307585-A1 Fluorescent whitening agent, for whitening synthetic or natural organic materials, especially paper and for the fluorescent whitening and improvement of sun protection factors of textile materials CIBA SPECIALTY CHEMICALS CORP. 2008-12-18 US claimed
US-20190214145-A1 Method and systems for creating and screening patient metabolite profile to diagnose current medical condition, diagnose current treatment state and recommend new treatment regimen KUREK ITZHAK (US) 2019-07-11 US disclosed
US-8124357-B2 Cell comprising exogenous clostridial toxin receptor for use as quality control agents in pharmaceutical and food processing ALLERGAN, INC. (US) 2012-02-28 US disclosed
EP-2417981-A1 Peptide PTTKTYFPHF and its uses CMS Peptides Patent Holding Company Limited (VG) 2012-02-15 EP disclosed
EP-1520073-B1 TRIAZINNYLAMINOSTILBENE DISULPHONIC ACID MIXTURES BASF SE (DE) 2012-01-18 EP disclosed
EP-1438586-B1 FRET PROTEASE ASSAYS FOR CLOSTRIDIAL TOXINS ALLERGAN INC (US) 2012-01-11 EP disclosed
EP-1901069-B1 Fret protease assays for clostridial toxins ALLERGAN INC (US) 2012-01-04 EP disclosed
US-8067231-B2 Clostridial toxin activity assays ALLERGAN, INC. (US) 2011-11-29 US disclosed
US-8053209-B2 FRET protease assays for clostridial toxins ALLERGAN, INC. (US) 2011-11-08 US disclosed
US-8013113-B2 FRET protease assays for clostridial toxins ALLERGAN, INC. (US) 2011-09-06 US disclosed
US-8003753-B2 Fret protease assays for clostridial toxins ALLERGAN, INC. (US) 2011-08-23 US disclosed
EP-2154151-B1 Clostridial toxin activatable clostridial toxins ALLERGAN INC (US) 2011-08-03 EP disclosed
US-20110111479-A1 Botulinum Neurotoxin Serotype B Activatable Botulinum Neurotoxin Serotype Bs ALLERGAN, INC. (US) 2011-05-12 US disclosed
EP-2316035-A2 THROMBIN SUBSTRATE AND ASSAY FOR DETERMINING THE LEVEL OF BIOACTIVE THROMBIN IN A SAMPLE Radiometer Medical ApS (DK) 2011-05-04 EP disclosed
EP-2292837-A1 Triazinylaminostilbene disulphonic acid mixtures BASF SE (DE) 2011-03-09 EP disclosed
CN-101501062-A Novel biologically active peptides and their new uses CMS MEDICAL SYSTEM HOLDING SHE (CN) 2009-08-05 CN disclosed
US-20050130941-A1 Methods of treating alzheimer's disease PHARMACIA & UPJOHN COMPANY LLC 2005-06-16 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050130941-A1 Methods of treating alzheimer's disease BACE1, PSEN1, BACE2 SLC1A2 544/4885SLC1A1 937/4885SLC1A3 1490/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.