Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Methamphetamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 known ✓ | P31645 | 4/20 | 0.73 |
| ▸ | SLC6A2 known ✓ | P23975 | 2/20 | 0.73 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.73 |
| ▸ | TAAR1 | Q96RJ0 | 5/20 | 0.81 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.81 |
| ▸ | SLC18A2 | Q05940 | 1/20 | 0.81 |
| ▸ | MAOA | P21397 | 1/20 | 0.73 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.73 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.73 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.73 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methamphetamine SCHEMBL4381141 | 1.00 | TAAR1 (0.81) | TAAR1SIGMAR1SLC18A2SLC6A4SLC6A2 | |
| Methamphetamine SCHEMBL15094025 | 1.00 | TAAR1 (0.81) | TAAR1SIGMAR1SLC18A2SLC6A4SLC6A2 | |
| Methamphetamine SCHEMBL2785177 | 1.00 | TAAR1 (0.81) | TAAR1SIGMAR1SLC18A2SLC6A4SLC6A2 | |
| Methamphetamine SCHEMBL4083435 | 1.00 | TAAR1 (0.81) | TAAR1SIGMAR1SLC18A2SLC6A4SLC6A2 | |
| Methamphetamine SCHEMBL29070829 | 0.98 | TAAR1 (0.78) | TAAR1SIGMAR1SLC18A2SLC6A4SLC6A2 | |
| Methamphetamine SCHEMBL9824299 | 0.90 | SIGMAR1 (0.84) | TAAR1SIGMAR1SLC18A2SLC6A4SLC6A2 | |
| Methamphetamine SCHEMBL42615 | 0.90 | SIGMAR1 (1.00) | TAAR1SIGMAR1SLC18A2SLC6A4CYP2D6 | |
| Methamphetamine SCHEMBL13747483 | 0.90 | SIGMAR1 (1.00) | TAAR1SIGMAR1SLC18A2SLC6A4CYP2D6 | |
| Methamphetamine SCHEMBL4781849 | 0.90 | SIGMAR1 (1.00) | TAAR1SIGMAR1SLC18A2SLC6A4CYP2D6 | |
| Levmetamfetamine SCHEMBL727412 | 0.90 | SIGMAR1 (1.00) | TAAR1SIGMAR1SLC18A2SLC6A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140006042-A1 | METHODS FOR CONDUCTING STUDIES | NEUROCOG TRIALS, INC. | 2014-01-02 | — | — | US | disclosed |
| WO-2012149472-A2 | METHODS, COMPOSITIONS, AND KITS FOR TREATING AND PREVENTING NEUROLOGICAL CONDITIONS | IGNITE INSTITUTE FOR INDIVIDUALIZED HEALTH (US) | 2012-11-01 | — | — | WO | disclosed |