Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Methamphetamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 known ✓ | P31645 | 4/20 | 0.73 |
| ▸ | SLC6A2 known ✓ | P23975 | 2/20 | 0.73 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.73 |
| ▸ | TAAR1 | Q96RJ0 | 5/20 | 0.81 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.81 |
| ▸ | SLC18A2 | Q05940 | 1/20 | 0.81 |
| ▸ | MAOA | P21397 | 1/20 | 0.73 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.73 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.73 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.73 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methamphetamine SCHEMBL4381141 | 1.00 | TAAR1 (0.81) | TAAR1SIGMAR1SLC18A2SLC6A4SLC6A2 | |
| Methamphetamine SCHEMBL15094025 | 1.00 | TAAR1 (0.81) | TAAR1SIGMAR1SLC18A2SLC6A4SLC6A2 | |
| Methamphetamine SCHEMBL13737281 | 1.00 | TAAR1 (0.81) | TAAR1SIGMAR1SLC18A2SLC6A4SLC6A2 | |
| Methamphetamine SCHEMBL2785177 | 1.00 | TAAR1 (0.81) | TAAR1SIGMAR1SLC18A2SLC6A4SLC6A2 | |
| Methamphetamine SCHEMBL29070829 | 0.98 | TAAR1 (0.78) | TAAR1SIGMAR1SLC18A2SLC6A4SLC6A2 | |
| Methamphetamine SCHEMBL9824299 | 0.90 | SIGMAR1 (0.84) | TAAR1SIGMAR1SLC18A2SLC6A4SLC6A2 | |
| Methamphetamine SCHEMBL42615 | 0.90 | SIGMAR1 (1.00) | TAAR1SIGMAR1SLC18A2SLC6A4CYP2D6 | |
| Methamphetamine SCHEMBL13747483 | 0.90 | SIGMAR1 (1.00) | TAAR1SIGMAR1SLC18A2SLC6A4CYP2D6 | |
| Methamphetamine SCHEMBL4781849 | 0.90 | SIGMAR1 (1.00) | TAAR1SIGMAR1SLC18A2SLC6A4CYP2D6 | |
| Levmetamfetamine SCHEMBL727412 | 0.90 | SIGMAR1 (1.00) | TAAR1SIGMAR1SLC18A2SLC6A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0983514-A1 | A PROCESS AND A TEST KIT FOR HEROIN DETECTION | Identa Ltd. (IL) | 2000-03-08 | — | — | EP | claimed |
| WO-1998045714-A1 | A PROCESS AND A TEST KIT FOR HEROIN DETECTION | IDENTA LTD. (IL) | 1998-10-15 | — | — | WO | claimed |
| EP-3701249-A1 | DETECTION METHOD | The University of Queensland (AU) | 2020-09-02 | — | — | EP | disclosed |
| CN-107684573-A | Purposes of the psoralea corylifolia in drug-breaking medicine and drug rehabilitation health food is prepared | 北京健旭康技术有限公司 | 2018-02-13 | — | — | CN | disclosed |
| US-9247901-B2 | Systems and methods for replacing signal artifacts in a glucose sensor data stream | DEXCOM, INC. (US) | 2016-02-02 | — | — | US | disclosed |
| WO-2013149250-A1 | METHODS OF TREATMENT, DIAGNOSIS AND MONITORING FOR METHAMPHETAMINE TOXICITY WHICH TARGET CERAMIDE METABOLIC PATHWAYS AND CELLULAR SENESCENCE | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2013-10-03 | — | — | WO | disclosed |
| CN-102252983-A | Deep ultraviolet spectrum measurement and spectrophotometry measurement device | CAPITALBIO CORP | 2011-11-23 | — | — | CN | disclosed |
| EP-1062511-B1 | IMMUNOASSAYS INVOLVING SURFACE ENHANCED RAMAN SCATTERING | UNIV STRATHCLYDE (GB) | 2009-11-25 | — | — | EP | disclosed |
| US-7560239-B2 | Homogeneous enzyme immunoassay for simultaneous detection of multiple analytes | LIN-ZHI INTERNATIONAL INC. (US) | 2009-07-14 | — | — | US | disclosed |
| EP-0983514-B1 | A PROCESS AND A TEST KIT FOR HEROIN DETECTION | IDENTA LTD (IL) | 2007-12-19 | — | — | EP | disclosed |
| EP-0983514-B1 | A PROCESS AND A TEST KIT FOR HEROIN DETECTION | IDENTA LTD (IL) | 2007-12-19 | — | — | EP | disclosed |
| EP-0983514-A1 | A PROCESS AND A TEST KIT FOR HEROIN DETECTION | Identa Ltd. (IL) | 2000-03-08 | — | — | EP | disclosed |
| EP-0983514-A1 | A PROCESS AND A TEST KIT FOR HEROIN DETECTION | Identa Ltd. (IL) | 2000-03-08 | — | — | EP | disclosed |
| WO-1999044065-A1 | IMMUNOASSAYS INVOLVING SURFACE ENHANCED RAMAN SCATTERING | UNIVERSITY OF STRATHCLYDE (GB) | 1999-09-02 | — | — | WO | disclosed |
| WO-1999022244-A2 | METHOD FOR DETERMINATION OF DRUGS OF ABUSE IN BIOLOGICAL SAMPLES | VARIAN, INC. (US) | 1999-05-06 | — | — | WO | disclosed |
| WO-1998045714-A1 | A PROCESS AND A TEST KIT FOR HEROIN DETECTION | IDENTA LTD. (IL) | 1998-10-15 | — | — | WO | disclosed |
| WO-1998045714-A1 | A PROCESS AND A TEST KIT FOR HEROIN DETECTION | IDENTA LTD. (IL) | 1998-10-15 | — | — | WO | disclosed |
| US-5532131-A | PREPARING A CONCENTRATED NEONATAL MECONIUM EXTRACT | Lewis, Douglas Edward (US) | 1996-07-02 | — | — | US | disclosed |
| US-5326708-A | Drug abuse | UNITED STATES DRUG TESTING LABORATORIES, INC. | 1994-07-05 | — | — | US | disclosed |
| EP-0279213-B1 | FLUORESCENCE POLARIZATION IMMUNOASSAY FOR AMPHETAMINE/METHAMPHETAMINE | ABBOTT LABORATORIES (US) | 1992-10-21 | — | — | EP | disclosed |