Pyruvate

Pyruvate

SCHEMBL1373746

CC(=O)C(=O)O.CC(C)CO

nearest known ligand 0.56

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Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.56
TDP1 Q9NUW8 2/20 0.43
ALDH1A1 P00352 2/20 0.43
CYP2D6 P10635 1/20 0.38
CYP2C19 P33261 1/20 0.38
OR51E2 Q9H255 1/20 0.36
RNPEP Q9H4A4 1/20 0.36
SLC7A5 Q01650 1/20 0.36
THPO P40225 1/20 0.35
FFAR3 O14843 1/20 0.35
LCK P06239 1/20 0.35
FYN P06241 1/20 0.35
TP53 P04637 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Pyruvate SCHEMBL27579359 0.97 TSHR (0.53) TSHRTDP1ALDH1A1CYP2D6CYP2C19
Isobutanol SCHEMBL10277757 0.87
Isobutanol SCHEMBL27702082 0.87 TSHR (0.64) TSHRTDP1ALDH1A1CYP2D6CYP2C19
Isobutanol SCHEMBL8909738 0.83
Methacrylic Acid SCHEMBL5683702 0.82 TSHR (0.50) TSHRTDP1ALDH1A1CYP2D6CYP2C19
Methacrylic Acid SCHEMBL3647938 0.82 TSHR (0.50) TSHRTDP1ALDH1A1CYP2D6CYP2C19
Methacrylic Acid SCHEMBL9397155 0.82 TSHR (0.50) TSHRTDP1ALDH1A1CYP2D6CYP2C19
Isobutanol SCHEMBL27873135 0.81 TSHR (0.56) TSHRTDP1ALDH1A1CYP2D6CYP2C19
Pyruvate SCHEMBL30531673 0.79 LMNA (0.53) TSHRTDP1ALDH1A1OR51E2THPO
Pyruvate SCHEMBL2052994 0.79 LMNA (0.53) TSHRTDP1ALDH1A1OR51E2THPO

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20180273985-A1 CELL-FREE PRODUCTION OF BUTANOL GREENLIGHT BIOSCIENCES, INC. 2018-09-27 US disclosed
US-20140308721-A1 Cytosolic Isobutanol Pathway Localization for the Production of Isobutanol GEVO, INC. (US) 2014-10-16 US disclosed
CN-102869763-A Yeast microorganisms for enhanced by-product accumulation reduction of fuel, chemical and amino acid production GEVO INC 2013-01-09 CN disclosed
US-8232089-B2 Cytosolic isobutanol pathway localization for the production of isobutanol GEVO, INC. (US) 2012-07-31 US disclosed
EP-2464736-A1 CYTOSOLIC ISOBUTANOL PATHWAY LOCALIZATION FOR THE PRODUCTION OF ISOBUTANOL Gevo, Inc. (US) 2012-06-20 EP disclosed
US-20110287500-A1 CYTOSOLIC ISOBUTANOL PATHWAY LOCALIZATION FOR THE PRODUCTION OF ISOBUTANOL GEVO, INC. (US) 2011-11-24 US disclosed
US-20110076733-A1 CYTOSOLIC ISOBUTANOL PATHWAY LOCALIZATION FOR THE PRODUCTION OF ISOBUTANOL GEVO, INC. (US) 2011-03-31 US disclosed