Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.41 |
| ▸ | CCR5 | P51681 | 6/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.36 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13738460 | 1.00 | HRH3 (0.43) | HRH3SMN1; SMN2OPRM1SIGMAR1CCR5 | |
| SCHEMBL15668110 | 1.00 | HRH3 (0.43) | HRH3SMN1; SMN2OPRM1SIGMAR1CCR5 | |
| SCHEMBL2053926 | 0.89 | SMN1; SMN2 (0.48) | HRH3SMN1; SMN2OPRM1SIGMAR1CCR5 | |
| SCHEMBL8418349 | 0.86 | LTA4H (0.44) | HRH3SMN1; SMN2SIGMAR1CCR5 | |
| SCHEMBL14155733 | 0.86 | LTA4H (0.44) | HRH3SMN1; SMN2SIGMAR1CCR5 | |
| SCHEMBL14155716 | 0.86 | LTA4H (0.44) | HRH3SMN1; SMN2SIGMAR1CCR5 | |
| SCHEMBL24326958 | 0.84 | SIGMAR1 (0.44) | HRH3SMN1; SMN2OPRM1SIGMAR1CCR5 | |
| SCHEMBL8422214 | 0.84 | HRH3 (0.42) | HRH3SMN1; SMN2OPRM1SIGMAR1CCR5 | |
| SCHEMBL3679202 | 0.81 | SIGMAR1 (0.42) | OPRM1SIGMAR1CCR5CYP1A2CYP3A4 | |
| SCHEMBL1306321 | 0.78 | SMN1; SMN2 (0.39) | HRH3SMN1; SMN2OPRM1SIGMAR1CCR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2916833-A1 | METHODS OF TREATING LIVER DISEASES | Zafgen, Inc. (US) | 2015-09-16 | — | — | EP | disclosed |
| WO-2014071368-A1 | METHODS OF TREATING LIVER DISEASES | ZAFGEN, INC. (US) | 2014-05-08 | — | — | WO | disclosed |
| WO-2012154676-A9 | PARTIALLY SATURATED TRICYCLIC COMPOUNDS AND METHODS OF MAKING AND USING SAME | ZAFGEN INC. (US) | 2014-03-27 | — | — | WO | disclosed |
| EP-2705030-A1 | PARTIALLY SATURATED TRICYCLIC COMPOUNDS AND METHODS OF MAKING AND USING SAME | ZAFGEN INC. (US) | 2014-03-12 | — | — | EP | disclosed |
| WO-2012154676-A1 | PARTIALLY SATURATED TRICYCLIC COMPOUNDS AND METHODS OF MAKING AND USING SAME | ZAFGEN CORPORATION (US) | 2012-11-15 | — | — | WO | disclosed |