Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 8/20 | 0.68 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | THRB | P10828 | 1/20 | 0.53 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | CFD | P00746 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31710264 | 0.88 | KMT2A (0.69) | EPHX2CYP2C9CYP2C19POLBKMT2A | |
| SCHEMBL31717905 | 0.87 | EPHX2 (0.66) | EPHX2CYP2C9CYP2C19POLBKMT2A | |
| SCHEMBL13873418 | 0.81 | EPHX2 (1.00) | EPHX2CYP2C9CYP2C19POLBTSHR | |
| SCHEMBL13720911 | 0.81 | EPHX2 (0.55) | EPHX2CYP2C9CYP2C19POLBCFD | |
| SCHEMBL13739125 | 0.81 | EPHX2 (0.55) | EPHX2CYP2C9CYP2C19POLBCFD | |
| SCHEMBL13873295 | 0.78 | EPHX2 (0.81) | EPHX2CYP2C9CYP2C19POLBKMT2A | |
| SCHEMBL27439912 | 0.78 | CYP2C19 (0.65) | CYP2C9CYP2C19GAAKMT2ATHRB | |
| SCHEMBL18620676 | 0.77 | PREP (0.68) | EPHX2GAA | |
| SCHEMBL22811419 | 0.77 | PREP (0.68) | EPHX2GAA | |
| SCHEMBL13873300 | 0.77 | EPHX2 (1.00) | EPHX2CYP2C9CYP2C19POLBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2707371-A1 | NEW HEXAHYDROPYRROLOIMIDAZOLONE COMPOUNDS | F.HOFFMANN-LA ROCHE AG (CH) | 2014-03-19 | — | — | EP | disclosed |
| WO-2012152663-A1 | NEW HEXAHYDROPYRROLOIMIDAZOLONE COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2012-11-15 | — | — | WO | disclosed |