Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 13/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | LIPE | Q05469 | 2/20 | 0.45 |
| ▸ | CFD | P00746 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13739125 | 1.00 | EPHX2 (0.55) | EPHX2POLBALDH1A1CYP2C9CYP2C19 | |
| SCHEMBL13721427 | 0.86 | KMT2A (0.44) | EPHX2POLBALDH1A1LIPE | |
| SCHEMBL13740312 | 0.86 | KMT2A (0.44) | EPHX2POLBALDH1A1LIPE | |
| SCHEMBL24012052 | 0.82 | POLB (0.55) | POLBALDH1A1 | |
| SCHEMBL13739448 | 0.81 | EPHX2 (0.68) | EPHX2POLBCYP2C9CYP2C19CFD | |
| SCHEMBL13720740 | 0.78 | EPHX2 (0.44) | EPHX2POLBCYP2C9CYP2C19LIPE | |
| SCHEMBL13873301 | 0.73 | EPHX2 (0.74) | EPHX2POLBCYP2C9CYP2C19LIPE | |
| SCHEMBL14254707 | 0.73 | ALDH1A1 (0.49) | POLBALDH1A1 | |
| SCHEMBL29580800 | 0.71 | NAMPT (0.46) | EPHX2CFD | |
| SCHEMBL13873418 | 0.71 | EPHX2 (1.00) | EPHX2POLBALDH1A1CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2707371-B1 | NEW HEXAHYDROPYRROLOIMIDAZOLONE COMPOUNDS | HOFFMANN LA ROCHE (CH) | 2016-04-20 | — | — | EP | disclosed |
| EP-2707371-B1 | NEW HEXAHYDROPYRROLOIMIDAZOLONE COMPOUNDS | HOFFMANN LA ROCHE (CH) | 2016-04-20 | — | — | EP | disclosed |
| US-8497288-B2 | Hexahydropyrroloimidazolone compounds | HOFFMANN-LA ROCHE INC. (US) | 2013-07-30 | — | — | US | disclosed |
| US-8497288-B2 | Hexahydropyrroloimidazolone compounds | HOFFMANN-LA ROCHE INC. (US) | 2013-07-30 | — | — | US | disclosed |
| US-8497288-B2 | Hexahydropyrroloimidazolone compounds | HOFFMANN-LA ROCHE INC. (US) | 2013-07-30 | — | — | US | disclosed |
| WO-2012152663-A1 | NEW HEXAHYDROPYRROLOIMIDAZOLONE COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2012-11-15 | — | — | WO | disclosed |
| US-20120289549-A1 | NEW HEXAHYDROPYRROLOIMIDAZOLONE COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2012-11-15 | — | — | US | disclosed |
| US-20120289549-A1 | NEW HEXAHYDROPYRROLOIMIDAZOLONE COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2012-11-15 | — | — | US | disclosed |
| US-20120289549-A1 | NEW HEXAHYDROPYRROLOIMIDAZOLONE COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2012-11-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120289549-A1 | NEW HEXAHYDROPYRROLOIMIDAZOLONE COMPOUNDS | LIPC, PNLIP, LIPE | EPHX2 2409/4885POLB 4754/4885ALDH1A1 325/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.