Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.54 |
| ▸ | MAPK13 | O15264 | 6/20 | 0.44 |
| ▸ | MAPK12 | P53778 | 6/20 | 0.44 |
| ▸ | MAPK11 | Q15759 | 6/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 6/20 | 0.44 |
| ▸ | HPGD | P15428 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | XDH | P47989 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | RAF1 | P04049 | 4/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | GCGR | P47871 | 1/20 | 0.37 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4105858 | 0.86 | MAPK13 (0.60) | NOTUMMAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL13741481 | 0.85 | CYP19A1 (0.44) | NOTUMMAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL13740498 | 0.83 | HPGD (0.64) | NOTUMMAPK13MAPK12MAPK11MAPK14 | |
| Trifluoroacetic Acid SCHEMBL4092771 | 0.80 | L3MBTL1 (0.41) | NOTUMMAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL8221938 | 0.79 | KDM4E (0.60) | MAPK13MAPK12MAPK11MAPK14HPGD | |
| SCHEMBL5762068 | 0.79 | MAPK13 (0.68) | MAPK13MAPK12MAPK11MAPK14RAF1 | |
| SCHEMBL5759775 | 0.78 | MAPK14 (0.61) | MAPK13MAPK12MAPK11MAPK14KMT2A | |
| SCHEMBL3618734 | 0.74 | MAPK13 (0.49) | MAPK13MAPK12MAPK11MAPK14RAF1 | |
| SCHEMBL1136802 | 0.72 | NOTUM (1.00) | NOTUMKDM4ESMN1; SMN2KMT2AMEN1 | |
| SCHEMBL13741397 | 0.71 | MAPK13 (0.49) | MAPK13MAPK12MAPK11MAPK14HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090215766-A1 | TETRACYCLIC INHIBITORS OF JANUS KINASES | INCYTE CORPORATION | 2009-08-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090215766-A1 | TETRACYCLIC INHIBITORS OF JANUS KINASES | JAK1, JAK2, JAK3 | NOTUM 3935/4885MAPK13 99/4885MAPK12 111/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.