Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.40 |
| ▸ | BRAF | P15056 | 2/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.37 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.37 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.37 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.37 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | CDC7 | O00311 | 1/20 | 0.35 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.35 |
| ▸ | KMO | O15229 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | PIKFYVE | Q9Y2I7 | 3/20 | 0.35 |
| ▸ | F2 | P00734 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13741481 | 0.90 | CYP19A1 (0.44) | CYP19A1BRAFMAPK14MAPK13MAPK12 | |
| Trifluoroacetic Acid SCHEMBL4091388 | 0.81 | CDC7 (0.40) | L3MBTL1CDC7DBF4 | |
| SCHEMBL13740667 | 0.80 | NOTUM (0.54) | L3MBTL1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL4096709 | 0.76 | MAPK14 (0.43) | CYP19A1BRAFMAPK14MAPK13MAPK12 | |
| SCHEMBL4105858 | 0.73 | MAPK13 (0.60) | BRAFMAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL4090706 | 0.71 | ADORA2B (0.57) | CYP19A1BRAFMAPK14MAPK13MAPK12 | |
| SCHEMBL13741720 | 0.71 | CDC7 (0.44) | CYP19A1MAPK14MAPTCDC7DBF4 | |
| SCHEMBL30494229 | 0.70 | NOTUM (0.61) | CYP19A1NOTUMKMOKMT2A | |
| SCHEMBL26462950 | 0.70 | NOTUM (0.61) | CYP19A1NOTUMKMOKMT2A | |
| SCHEMBL5762068 | 0.66 | MAPK13 (0.68) | BRAFMAPK14MAPK13MAPK12MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090215766-A1 | TETRACYCLIC INHIBITORS OF JANUS KINASES | INCYTE CORPORATION | 2009-08-27 | — | — | US | disclosed |
| US-20060106020-A1 | Tetracyclic inhibitors of Janus kinases | INCYTE CORPORATION | 2006-05-18 | — | — | US | disclosed |
| WO-2005105814-A1 | TETRACYCLIC INHIBITORS OF JANUS KINASES | INCYTE CORPORATION (US) | 2005-11-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090215766-A1 | TETRACYCLIC INHIBITORS OF JANUS KINASES | JAK1, JAK2, JAK3 | L3MBTL1 2080/4885CYP19A1 4129/4885BRAF 161/4885 |
| US-20060106020-A1 | Tetracyclic inhibitors of Janus kinases | JAK1, JAK2, JAK3 | L3MBTL1 2080/4885CYP19A1 4129/4885BRAF 161/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.