Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Clemastine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 3/20 | 0.81 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.81 |
| ▸ | CHRM3 | P20309 | 4/20 | 0.81 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.81 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.81 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.81 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.81 |
| ▸ | HTR1A | P08908 | 2/20 | 0.81 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.81 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.81 |
| ▸ | DRD1 | P21728 | 2/20 | 0.81 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.81 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.81 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.81 |
| ▸ | DRD3 | P35462 | 2/20 | 0.81 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.81 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.81 |
| ▸ | MLNR | O43193 | 1/20 | 0.81 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.81 |
| ▸ | TP53 | P04637 | 1/20 | 0.81 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Clemastine SCHEMBL13740538 | 0.94 | CHRM3 (0.72) | ADRA1ACHRM3KCNH2HRH3HRH1 | |
| Clemastine SCHEMBL13740341 | 0.94 | ADRA1A (0.72) | ADRA1ACHRM3KCNH2HRH3HRH1 | |
| Clemastine SCHEMBL13740478 | 0.94 | ADRA1A (0.72) | ADRA1ACHRM3KCNH2HRH3HRH1 | |
| Clemastine SCHEMBL4098096 | 0.91 | ADRA1A (0.73) | ADRA1ACHRM3KCNH2HRH3HRH1 | |
| Clemastine SCHEMBL4095494 | 0.91 | ADRA1A (0.73) | ADRA1ACHRM3KCNH2HRH3HRH1 | |
| Clemastine SCHEMBL13740536 | 0.91 | ADRA1A (0.73) | ADRA1ACHRM3KCNH2HRH3HRH1 | |
| Clemastine SCHEMBL23785540 | 0.90 | CHRM3 (1.00) | ADRA1ACHRM3KCNH2HRH3HRH1 | |
| Clemastine SCHEMBL4087919 | 0.90 | CHRM3 (1.00) | ADRA1ACHRM3KCNH2HRH3HRH1 | |
| Clemastine SCHEMBL23785539 | 0.90 | CHRM3 (1.00) | ADRA1ACHRM3KCNH2HRH3HRH1 | |
| Clemastine SCHEMBL727373 | 0.90 | CHRM3 (1.00) | ADRA1ACHRM3KCNH2HRH3HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090203763-A1 | SUBSTITUTED BENZHYDRYLETHERS | AUSPEX PHARMACEUTICALS, INC. (US) | 2009-08-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090203763-A1 | SUBSTITUTED BENZHYDRYLETHERS | UGT2B7, CYP3A7, CYP3A43 | HRH1 265/4885ADRA1A 764/4885CHRM3 2837/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.