Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.39 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.39 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | TLR7 | Q9NYK1 | 3/20 | 0.37 |
| ▸ | PNP | P00491 | 2/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.37 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4090773 | 0.88 | CHEK1 (0.53) | HSD17B10KMT2AALDH1A1CHEK1JAK2 | |
| SCHEMBL5763548 | 0.76 | CHEK1 (0.56) | KMT2AALDH1A1SMN1; SMN2RAB9ALMNA | |
| SCHEMBL13740523 | 0.69 | EGLN1 (0.35) | KDM4ECYP1A2CYP2C9CYP2C19KMT2A | |
| SCHEMBL2967938 | 0.67 | PNP (0.49) | KDM4EHSD17B10KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL20432200 | 0.66 | DPP4 (0.65) | KDM4EKMT2AALDH1A1RAB9APNP | |
| SCHEMBL5761641 | 0.66 | CHEK1 (0.57) | CHEK1JAK2JAK1TYK2JAK3 | |
| SCHEMBL13740987 | 0.65 | JAK2 (0.48) | KDM4ECYP1A2CYP2C9HSD17B10TDP1 | |
| SCHEMBL30275441 | 0.63 | ADORA3 (0.51) | KMT2ASMN1; SMN2RAB9AADORA3HPGD | |
| SCHEMBL4098541 | 0.63 | CHEK1 (0.42) | KDM4EHSD17B10KMT2AALDH1A1ADORA3 | |
| SCHEMBL22105477 | 0.63 | MEN1 (0.68) | KDM4EHSD17B10KMT2AALDH1A1ADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090215766-A1 | TETRACYCLIC INHIBITORS OF JANUS KINASES | INCYTE CORPORATION | 2009-08-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090215766-A1 | TETRACYCLIC INHIBITORS OF JANUS KINASES | JAK1, JAK2, JAK3 | KDM4E 867/4885CYP1A2 3396/4885CYP2C9 3142/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.