Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 4/20 | 0.42 |
| ▸ | PARP1 | P09874 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | TYMS | P04818 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.35 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 2/20 | 0.34 |
| ▸ | JAK1 | P23458 | 2/20 | 0.34 |
| ▸ | TNKS | O95271 | 2/20 | 0.34 |
| ▸ | TNKS2 | Q9H2K2 | 2/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.34 |
| ▸ | ELANE | P08246 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2358555 | 0.87 | CHEK1 (0.60) | CHEK1PIM1CLK4JAK2JAK1 | |
| SCHEMBL4099692 | 0.82 | CHEK1 (0.42) | CHEK1PARP1ALDH1A1TYMSPIM1 | |
| SCHEMBL13741467 | 0.81 | TLR8 (0.48) | CHEK1PARP1ALDH1A1TYMSPIM1 | |
| SCHEMBL24476715 | 0.77 | ADORA3 (0.44) | ALDH1A1MEN1KMT2AMAPTADORA3 | |
| SCHEMBL4096833 | 0.77 | PARP1 (0.37) | CHEK1PARP1ALDH1A1TYMSPIM1 | |
| SCHEMBL4341946 | 0.74 | ALDH1A1 (0.41) | PARP1ALDH1A1MEN1KMT2APIM1 | |
| SCHEMBL28561318 | 0.74 | SMN1; SMN2 (0.47) | PARP1ALDH1A1MEN1KMT2APIM1 | |
| SCHEMBL6103033 | 0.74 | ELANE (0.41) | CHEK1PARP1ALDH1A1MEN1KMT2A | |
| SCHEMBL11285870 | 0.70 | PARP1 (0.45) | PARP1ALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL14703208 | 0.69 | ALDH1A1 (0.46) | ALDH1A1MEN1KMT2AMAPTADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090215766-A1 | TETRACYCLIC INHIBITORS OF JANUS KINASES | INCYTE CORPORATION | 2009-08-27 | — | — | US | disclosed |
| US-20060106020-A1 | Tetracyclic inhibitors of Janus kinases | INCYTE CORPORATION | 2006-05-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090215766-A1 | TETRACYCLIC INHIBITORS OF JANUS KINASES | JAK1, JAK2, JAK3 | CHEK1 412/4885PARP1 1861/4885ALDH1A1 3857/4885 |
| US-20060106020-A1 | Tetracyclic inhibitors of Janus kinases | JAK1, JAK2, JAK3 | CHEK1 412/4885PARP1 1861/4885ALDH1A1 3857/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.