Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPY5R | Q15761 | 1/20 | 0.52 |
| ▸ | GPR132 | Q9UNW8 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.49 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.49 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.48 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.47 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.45 |
| ▸ | ABL1 | P00519 | 3/20 | 0.45 |
| ▸ | BCR | P11274 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.44 |
| ▸ | IDO1 | P14902 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28048524 | 0.83 | MAPK1 (0.64) | GPR132CYP11B1CYP11B2MAPK1RAB9A | |
| SCHEMBL5105144 | 0.82 | MRGPRX4 (0.58) | CYP2C19MRGPRX4FFAR1RAB9A | |
| SCHEMBL8103834 | 0.80 | NPY5R (0.65) | NPY5RCYP3A4CYP2C9CYP2C19CYP11B1 | |
| SCHEMBL8361588 | 0.77 | MAPK1 (0.58) | CYP3A4CYP2C9CYP2C19CYP11B1CYP11B2 | |
| SCHEMBL5784957 | 0.76 | MRGPRX4 (0.63) | CYP2C19MRGPRX4RAB9A | |
| SCHEMBL7311175 | 0.76 | MAPK1 (0.65) | GPR132MAPK1RAB9A | |
| Ammonia Solution, Strong SCHEMBL23291318 | 0.76 | MAPK1 (0.57) | CYP3A4CYP2C9CYP2C19CYP11B1CYP11B2 | |
| SCHEMBL1957530 | 0.76 | MAPK1 (0.61) | CYP3A4CYP2C9CYP2C19CYP11B1CYP11B2 | |
| SCHEMBL4060132 | 0.75 | MAPK1 (0.56) | GPR132CYP11B1CYP11B2MAPK1MRGPRX4 | |
| SCHEMBL8041706 | 0.75 | MAPK1 (0.56) | GPR132CYP11B1CYP11B2MAPK1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2707361-A1 | FUSED HETEROCYCLIC COMPOUNDS AS SODIUM CHANNEL MODULATORS | Gilead Sciences, Inc. (US) | 2014-03-19 | — | — | EP | disclosed |
| WO-2012154760-A1 | FUSED HETEROCYCLIC COMPOUNDS AS SODIUM CHANNEL MODULATORS | GILEAD SCIENCES, INC. (US) | 2012-11-15 | — | — | WO | disclosed |