Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 9/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | TP53 | P04637 | 3/20 | 0.44 |
| ▸ | HSP90AB1 | P08238 | 7/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19948805 | 0.86 | SMN1; SMN2 (0.48) | POLBSMN1; SMN2TP53KDM4EALDH1A1 | |
| SCHEMBL9839114 | 0.70 | LMNA (0.58) | POLBSMN1; SMN2MAPTLMNATP53 | |
| SCHEMBL6663539 | 0.67 | — | — | |
| SCHEMBL10498542 | 0.67 | LMNA (0.70) | POLBSMN1; SMN2MAPTLMNAKDM4E | |
| SCHEMBL2806475 | 0.66 | POLB (0.57) | POLBSMN1; SMN2MAPTLMNATP53 | |
| SCHEMBL9933161 | 0.65 | AHR (0.38) | — | |
| SCHEMBL2810511 | 0.65 | SMN1; SMN2 (0.56) | POLBSMN1; SMN2MAPTLMNAALDH1A1 | |
| SCHEMBL13740977 | 0.65 | POLB (0.40) | POLBSMN1; SMN2MAPTLMNATP53 | |
| SCHEMBL9685225 | 0.63 | MKNK2 (0.51) | POLBSMN1; SMN2MAPTKDM4EALDH1A1 | |
| SCHEMBL10519806 | 0.63 | ALDH1A1 (0.44) | SMN1; SMN2TP53KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2702064-A1 | KINASE INHIBITORS | Icahn School of Medicine at Mount Sinai (US) | 2014-03-05 | — | — | EP | disclosed |
| WO-2012149567-A1 | KINASE INHIBITORS | MOUNT SINAI SCHOOL OF MEDICINE (US) | 2012-11-01 | — | — | WO | disclosed |