Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 11/20 | 0.73 |
| ▸ | PTGS1 | P23219 | 6/20 | 0.73 |
| ▸ | PGR | P06401 | 4/20 | 0.47 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.46 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8112979 | 0.85 | PTGS2 (0.68) | PTGS2PTGS1PGRNR3C1NR3C2 | |
| SCHEMBL439345 | 0.84 | PTGS2 (1.00) | PTGS2PTGS1 | |
| SCHEMBL29748909 | 0.84 | PTGS2 (1.00) | PTGS2PTGS1 | |
| SCHEMBL27456659 | 0.83 | PTGS2 (0.80) | PTGS2PTGS1PGR | |
| SCHEMBL27457609 | 0.82 | PTGS2 (0.64) | PTGS2PTGS1PGRNR3C1NR3C2 | |
| SCHEMBL8112981 | 0.81 | PTGS2 (0.56) | PTGS2PTGS1PGRNR3C1NR3C2 | |
| SCHEMBL13751996 | 0.80 | PTGS2 (0.61) | PTGS2PTGS1PGRNR3C1NR3C2 | |
| SCHEMBL6734121 | 0.80 | PTGS2 (0.71) | PTGS2PTGS1PGRNR3C1NR3C2 | |
| SCHEMBL13866612 | 0.80 | PTGS2 (0.61) | PTGS2PTGS1PGRNR3C1NR3C2 | |
| SCHEMBL27589152 | 0.79 | PTGS2 (0.56) | PTGS2PTGS1PGRNR3C1NR3C2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090197833-A1 | Silicon Containing Compounds Having Selective Cox-2 Inhibitory Activity and Methods of Making and Using the Same | ENGLEBIENNE & ASSOCIATES (BE) | 2009-08-06 | — | — | US | disclosed |
| US-20090192211-A1 | CYCLOOXYGENASE-2 INHIBITOR/HISTONE DEACETYLASE INHIBITOR COMBINATION | CHEN YING-NAN PAN | 2009-07-30 | — | — | US | disclosed |
| US-20080227845-A1 | CYCLOOXYGENASE-2 INHIBITOR/HISTONE DEACETYLASE INHIBITOR COMBINATION | CHEN YING-NAN PAN | 2008-09-18 | — | — | US | disclosed |
| US-7402603-B2 | Cyclooxygenase-2 inhibitor/histone deacetylase inhibitor combination | NOVARTIS AG (CH) | 2008-07-22 | — | — | US | disclosed |
| US-7345088-B2 | Pharmaceutical composition for use for the treatment of malignancies comprising in combination a bisphosphonates, a cox-2 inhibitor and a taxol | PENN STATE RESEARCH FOUNDATION (US) | 2008-03-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090192211-A1 | CYCLOOXYGENASE-2 INHIBITOR/HISTONE DEACETYLASE INHIBITOR COMBINATION | HDAC2, HDAC9, HDAC1 | PTGS2 6/4885PTGS1 13/4885PGR 1387/4885 |
| US-20080227845-A1 | CYCLOOXYGENASE-2 INHIBITOR/HISTONE DEACETYLASE INHIBITOR COMBINATION | HDAC2, HDAC9, HDAC1 | PTGS2 6/4885PTGS1 13/4885PGR 1387/4885 |
| US-20090197833-A1 | Silicon Containing Compounds Having Selective Cox-2 Inhibitory Activity and Methods of Making and Using the Same | PTGS2, PTGES2, PTGS1 | PTGS2 1/4885PTGS1 3/4885PGR 1953/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.