SCHEMBL8112979

SCHEMBL8112979

CSc1ccc(C2=C(c3cccc(F)c3)C(=O)OC2(C)C)cc1

nearest known ligand 0.68

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
PTGS2 P35354 13/20 0.68
PTGS1 P23219 7/20 0.68
PGR P06401 4/20 0.44
NR3C1 P04150 1/20 0.43
NR3C2 P08235 1/20 0.43
MAPK13 O15264 1/20 0.39
MAPK12 P53778 1/20 0.39
MAPK11 Q15759 1/20 0.39
MAPK14 Q16539 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8902056 0.87 PTGS2 (0.56) PTGS2PTGS1PGRNR3C1NR3C2
SCHEMBL13742829 0.85 PTGS2 (0.73) PTGS2PTGS1PGRNR3C1NR3C2
SCHEMBL13866612 0.82 PTGS2 (0.61) PTGS2PTGS1PGRNR3C1NR3C2
SCHEMBL6997433 0.81 PTGS2 (0.46) PTGS2PTGS1PGRMAPK13MAPK12
SCHEMBL439345 0.81 PTGS2 (1.00) PTGS2PTGS1
SCHEMBL29748909 0.81 PTGS2 (1.00) PTGS2PTGS1
SCHEMBL27456659 0.80 PTGS2 (0.80) PTGS2PTGS1PGR
SCHEMBL27457609 0.79 PTGS2 (0.64) PTGS2PTGS1PGRNR3C1NR3C2
SCHEMBL13751996 0.77 PTGS2 (0.61) PTGS2PTGS1PGRNR3C1NR3C2
SCHEMBL6734121 0.75 PTGS2 (0.71) PTGS2PTGS1PGRNR3C1NR3C2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0882016-B1 ALKYLATED STYRENES AS PRODRUGS TO COX-2 INHIBITORS MERCK FROSST CANADA INC (CA) 2000-05-31 EP disclosed
US-5925631-A NOVEL PRODRUGS ARE CONVERTED IN VIVO TO SELECTIVE CYCLOOXYGENASE-2 INHIBITORS; NONSTEROIDAL ANTIINFLAMMATORY AGENTS; SIDE EFFECT REDUCTION MERCK & CO., INC. (US) 1999-07-20 US disclosed
EP-0882016-A1 ALKYLATED STYRENES AS PRODRUGS TO COX-2 INHIBITORS MERCK FROSST CANADA INC. (CA) 1998-12-09 EP disclosed
US-5789413-A ANTIINFLAMMATORY AGENT MERCK FROSST CANADA, INC. (CA) 1998-08-04 US disclosed
WO-1997028121-A1 ALKYLATED STYRENES AS PRODRUGS TO COX-2 INHIBITORS MERCK FROSST CANADA INC. (CA) 1997-08-07 WO disclosed