Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 10/20 | 0.77 |
| ▸ | RAB9A | P51151 | 10/20 | 0.77 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.77 |
| ▸ | TP53 | P04637 | 3/20 | 0.77 |
| ▸ | TSHR | P16473 | 1/20 | 0.77 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.74 |
| ▸ | POLB | P06746 | 1/20 | 0.74 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.74 |
| ▸ | LMNA | P02545 | 2/20 | 0.69 |
| ▸ | HTT | P42858 | 2/20 | 0.69 |
| ▸ | MEN1 | O00255 | 1/20 | 0.69 |
| ▸ | GAA | P10253 | 1/20 | 0.69 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.62 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.62 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.62 |
| ▸ | PKM | P14618 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2241896 | 0.87 | RAB9A (1.00) | NPC1RAB9ASMN1; SMN2TP53TSHR | |
| SCHEMBL2246129 | 0.85 | NPC1 (1.00) | NPC1RAB9ASMN1; SMN2TP53TSHR | |
| SCHEMBL30354865 | 0.85 | NPC1 (0.77) | NPC1RAB9ASMN1; SMN2TP53TSHR | |
| SCHEMBL2248644 | 0.85 | NPC1 (1.00) | NPC1RAB9ASMN1; SMN2TP53TSHR | |
| SCHEMBL2245506 | 0.85 | RAB9A (1.00) | NPC1RAB9ASMN1; SMN2TP53TSHR | |
| SCHEMBL16938652 | 0.84 | NPC1 (0.71) | NPC1RAB9ASMN1; SMN2TP53TSHR | |
| SCHEMBL7199695 | 0.82 | NPC1 (0.77) | NPC1RAB9ASMN1; SMN2TP53TSHR | |
| SCHEMBL5007637 | 0.82 | NPC1 (1.00) | NPC1RAB9ASMN1; SMN2TP53TSHR | |
| SCHEMBL25437311 | 0.79 | NPC1 (0.68) | NPC1RAB9ASMN1; SMN2TP53TSHR | |
| SCHEMBL30354827 | 0.79 | NPC1 (0.68) | NPC1RAB9ASMN1; SMN2TP53TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009100438-A2 | COMPOUNDS THAT ENHANCE ATOH-1 EXPRESSION | MASSACHUSETTS EYE & EAR INFIRMARY (US) | 2009-08-13 | — | — | WO | disclosed |