Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.85 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.85 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.85 |
| ▸ | NPC1 | O15118 | 1/20 | 0.85 |
| ▸ | TSHR | P16473 | 1/20 | 0.85 |
| ▸ | RAB9A | P51151 | 1/20 | 0.85 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
| ▸ | OXTR | P30559 | 1/20 | 0.39 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4027665 | 0.81 | MEN1 (0.79) | MEN1KMT2ASMN1; SMN2NPC1TSHR | |
| SCHEMBL2046426 | 0.81 | SMN1; SMN2 (0.79) | MEN1KMT2ASMN1; SMN2NPC1TSHR | |
| SCHEMBL13729565 | 0.79 | MEN1 (0.73) | MEN1KMT2ASMN1; SMN2NPC1TSHR | |
| SCHEMBL13750580 | 0.78 | KMT2A (0.52) | MEN1KMT2ASMN1; SMN2NPC1TSHR | |
| SCHEMBL13745350 | 0.78 | KMT2A (0.51) | MEN1KMT2ASMN1; SMN2NPC1TSHR | |
| SCHEMBL13745349 | 0.78 | KMT2A (0.51) | MEN1KMT2ASMN1; SMN2NPC1TSHR | |
| SCHEMBL753331 | 0.76 | BCAT2 (0.60) | MEN1KMT2ASMN1; SMN2NPC1TSHR | |
| SCHEMBL29392331 | 0.76 | SMN1; SMN2 (0.69) | MEN1KMT2ASMN1; SMN2NPC1TSHR | |
| SCHEMBL134448 | 0.76 | SMN1; SMN2 (0.69) | MEN1KMT2ASMN1; SMN2NPC1TSHR | |
| SCHEMBL4799888 | 0.75 | MEN1 (0.49) | MEN1KMT2ASMN1; SMN2NPC1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009095377-A1 | SPIRO COMPOUNDS AS NPY Y5 RECEPTOR ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2009-08-06 | — | — | WO | disclosed |