Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | PDE2A | O00408 | 1/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | GPR142 | Q7Z601 | 1/20 | 0.36 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.36 |
| ▸ | MRGPRX1 | Q96LB2 | 2/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.34 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.34 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13745350 | 0.81 | KMT2A (0.51) | KMT2AMEN1NPC1TSHRRAB9A | |
| SCHEMBL4020558 | 0.81 | BCAT2 (0.53) | KMT2AMEN1NPC1TSHRRAB9A | |
| SCHEMBL17562268 | 0.79 | MEN1 (0.34) | KMT2AMEN1NPC1TSHRRAB9A | |
| SCHEMBL13745000 | 0.78 | MEN1 (0.85) | KMT2AMEN1NPC1TSHRRAB9A | |
| SCHEMBL13750581 | 0.77 | KMT2A (0.47) | KMT2AMEN1NPC1TSHRRAB9A | |
| SCHEMBL4050755 | 0.77 | MEN1 (0.53) | KMT2AMEN1NPC1TSHRRAB9A | |
| SCHEMBL4654446 | 0.72 | RXRA (0.47) | HSD11B1HCAR1SCN9ASLC6A2SLC6A4 | |
| SCHEMBL10762482 | 0.71 | KDM4E (0.51) | KMT2AMEN1HPGDMRGPRX1SCN9A | |
| SCHEMBL31482683 | 0.70 | KMT2A (0.46) | KMT2AMEN1NPC1TSHRRAB9A | |
| SCHEMBL753331 | 0.70 | BCAT2 (0.60) | KMT2AMEN1NPC1TSHRRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009095377-A1 | SPIRO COMPOUNDS AS NPY Y5 RECEPTOR ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2009-08-06 | — | — | WO | disclosed |