Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC5A2 | P31639 | 2/20 | 0.43 |
| ▸ | P2RX3 | P56373 | 3/20 | 0.38 |
| ▸ | P2RX2 | Q9UBL9 | 3/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.35 |
| ▸ | PDE4A | P27815 | 5/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.35 |
| ▸ | SYK | P43405 | 1/20 | 0.35 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.35 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.35 |
| ▸ | RET | P07949 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29549714 | 0.84 | SLC5A2 (0.48) | SLC5A2P2RX3P2RX2PDE4DPDE4A | |
| SCHEMBL23554570 | 0.84 | SLC5A2 (0.48) | SLC5A2P2RX3P2RX2PDE4DPDE4A | |
| SCHEMBL13750591 | 0.79 | PDE9A (0.43) | SLC5A2P2RX3P2RX2PDE10ASYK | |
| SCHEMBL23530040 | 0.76 | SLC5A2 (0.42) | SLC5A2P2RX3P2RX2PDE4DPDE4A | |
| SCHEMBL4029669 | 0.76 | BCAT2 (0.40) | SLC5A2PDE10ASYKKAT2BBAZ2B | |
| SCHEMBL3299242 | 0.76 | LRRK2 (0.37) | SLC5A2SYKKAT2BBAZ2BLRRK2 | |
| SCHEMBL13730320 | 0.75 | SYK (0.38) | SLC5A2P2RX3P2RX2PDE4DPDE4A | |
| SCHEMBL15829863 | 0.74 | PDE10A (0.39) | PDE4DPDE4APDE4BPDE4CPDE10A | |
| SCHEMBL13662044 | 0.74 | SCN9A (0.44) | P2RX3SYKLRRK2RETHDAC6 | |
| SCHEMBL20216122 | 0.74 | MBOAT4 (0.43) | P2RX3P2RX2PDE4DPDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009095377-A1 | SPIRO COMPOUNDS AS NPY Y5 RECEPTOR ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2009-08-06 | — | — | WO | disclosed |