Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 1/20 | 0.52 |
| ▸ | CCR5 | P51681 | 1/20 | 0.52 |
| ▸ | CCR8 | P51685 | 1/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | METAP2 | P50579 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.38 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.38 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.37 |
| ▸ | KDM1A | O60341 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL469189 | 0.84 | — | — | |
| SCHEMBL14804380 | 0.82 | CCR1 (0.76) | CCR1CCR5CCR8HDAC6CYP3A4 | |
| SCHEMBL13745161 | 0.81 | NPC1 (0.42) | NPC1RAB9ASMN1; SMN2PTGS2PTGS1 | |
| SCHEMBL17051522 | 0.81 | CCR1 (0.65) | CCR1CCR5CCR8HDAC6CYP3A4 | |
| SCHEMBL17051514 | 0.78 | CCR1 (0.75) | CCR1CCR5CCR8HDAC6CYP3A4 | |
| SCHEMBL26040044 | 0.78 | PRMT5 (0.46) | PTGS2PTGS1PRMT5WDR77PDE10A | |
| SCHEMBL8233550 | 0.78 | CCR1 (0.56) | CCR1CCR5CCR8HDAC6CYP3A4 | |
| SCHEMBL3426229 | 0.77 | CYP3A4 (0.61) | CCR1CCR5CCR8HDAC6CYP3A4 | |
| SCHEMBL17051547 | 0.77 | CCR1 (0.60) | CCR1CCR5CCR8HDAC6CYP3A4 | |
| SCHEMBL2477927 | 0.76 | CCR1 (0.71) | CCR1CCR5CCR8HDAC6CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009095377-A1 | SPIRO COMPOUNDS AS NPY Y5 RECEPTOR ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2009-08-06 | — | — | WO | disclosed |