Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | BRS3 | P32247 | 3/20 | 0.40 |
| ▸ | GRM5 | P41594 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | GRIA2 | P42262 | 3/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.38 |
| ▸ | LCK | P06239 | 1/20 | 0.38 |
| ▸ | CSF1R | P07333 | 1/20 | 0.38 |
| ▸ | RET | P07949 | 1/20 | 0.38 |
| ▸ | MET | P08581 | 1/20 | 0.38 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.38 |
| ▸ | FLT3 | P36888 | 1/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2336915 | 0.85 | — | — | |
| SCHEMBL22186144 | 0.82 | PRMT5 (0.40) | NPC1GRM5RAB9ASMN1; SMN2KCNH2 | |
| SCHEMBL13745159 | 0.81 | CCR1 (0.52) | NPC1RAB9ASMN1; SMN2GRIA2AURKA | |
| SCHEMBL3823523 | 0.80 | GRM5 (0.41) | NPC1RXFP1BRS3GRM5GRIA2 | |
| SCHEMBL3823318 | 0.79 | RAB9A (0.53) | NPC1RXFP1BRS3RAB9ASMN1; SMN2 | |
| SCHEMBL26040044 | 0.77 | PRMT5 (0.46) | PTGS1PTGS2PRMT5WDR77 | |
| SCHEMBL13750539 | 0.77 | TDO2 (0.46) | NPC1RXFP1BRS3GRM5GRIA2 | |
| SCHEMBL7945448 | 0.74 | MMP13 (0.42) | — | |
| SCHEMBL12533576 | 0.74 | CYP1A2 (0.50) | NPC1BRS3GRM5RAB9ASMN1; SMN2 | |
| SCHEMBL4024197 | 0.73 | TDO2 (0.46) | NPC1RXFP1RAB9APTPN1PTPN6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009095377-A1 | SPIRO COMPOUNDS AS NPY Y5 RECEPTOR ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2009-08-06 | — | — | WO | disclosed |