SCHEMBL1374533

SCHEMBL1374533

Nc1cccc(O)c1CO

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALOX15 P16050 4/20 0.50
TSHR P16473 4/20 0.50
ALDH1A1 P00352 5/20 0.38
HPGD P15428 3/20 0.38
HSD17B10 Q99714 3/20 0.38
TDP1 Q9NUW8 3/20 0.38
LMNA P02545 3/20 0.38
EGFR P00533 2/20 0.38
CA2 P00918 2/20 0.38
FYN P06241 2/20 0.38
MMP9 P14780 2/20 0.38
RECQL P46063 2/20 0.38
MMP2 P08253 2/20 0.38
ADAMTS4 O75173 1/20 0.38
CA1 P00915 1/20 0.38
MMP8 P22894 1/20 0.38
CA6 P23280 1/20 0.38
CDK2 P24941 1/20 0.38
MMP12 P39900 1/20 0.38
ADAMTS5 Q9UNA0 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28179325 0.85 TSHR (0.43) ALOX15TSHRALDH1A1HPGDHSD17B10
SCHEMBL7201903 0.82 ALOX15 (0.46) ALOX15TSHRALDH1A1HPGDHSD17B10
SCHEMBL4551579 0.82 ALDH1A1 (0.47) ALOX15TSHRALDH1A1HPGDHSD17B10
SCHEMBL1033771 0.81 ALOX15 (0.50) ALOX15TSHRALDH1A1HPGDHSD17B10
SCHEMBL7640576 0.79 TSHR (0.48) ALOX15TSHRALDH1A1HPGDHSD17B10
SCHEMBL1425126 0.79 ALOX15 (0.48) ALOX15TSHRALDH1A1HPGDHSD17B10
SCHEMBL5341513 0.79 ALOX15 (0.48) ALOX15TSHRALDH1A1HPGDHSD17B10
SCHEMBL10890690 0.79 TSHR (0.43) ALOX15TSHRALDH1A1HPGDHSD17B10
Hydrochloric Acid SCHEMBL28211444 0.77 TSHR (0.46) ALOX15TSHRALDH1A1HPGDHSD17B10
SCHEMBL2123567 0.76 CYP3A4 (0.42) ALOX15TSHRALDH1A1HPGDHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2592083-A1 FUSED QUINAZOLINE DERIVATIVES AND USES THEREOF Shenzhen Salubris Pharmaceuticals Co., Ltd. (CN) 2013-05-15 EP disclosed
US-20110288086-A1 POLYCYCLIC QUINAZOLINES, PREPARATION THEREOF, AND USE THEREOF SHENZHEN SALUBRIS PHARMACEUTICALS CO., LTD. (CN) 2011-11-24 US disclosed
EP-2352483-A1 HAIR COLOURING METHOD COMPRISING AFTERTREATMENT Henkel AG & Co. KGaA (DE) 2011-08-10 EP disclosed
EP-2315576-A1 CATIONIC ACETYLPYRIDINIUM DERIVATIVES FOR USE AS BLEACH ACTIVATORS Henkel AG & Co. KGaA (DE) 2011-05-04 EP disclosed
EP-2306967-A1 COLORATION USING CATIONIZABLE POLYMER Henkel AG & Co. KGaA (DE) 2011-04-13 EP disclosed
US-20100280072-A1 2-'4-(HYDROXYMETHYL-PHENYLAMINO) -PIPERIDINE-1-YL!-N- (9H-CARBAZOL-3YL) - ACETAMINE DERIVATIVES AND RELATED COMPOUNDS AS NEUROPEPTIDE Y5 (NPY5) LIGANDS FOR THE TREATMENT OF OBESITY LABORATORIOS DEL DR. ESTEVE S.A (ES) 2010-11-04 US disclosed
US-20100280072-A1 2-'4-(HYDROXYMETHYL-PHENYLAMINO) -PIPERIDINE-1-YL!-N- (9H-CARBAZOL-3YL) - ACETAMINE DERIVATIVES AND RELATED COMPOUNDS AS NEUROPEPTIDE Y5 (NPY5) LIGANDS FOR THE TREATMENT OF OBESITY LABORATORIOS DEL DR. ESTEVE S.A (ES) 2010-11-04 US disclosed
US-20100280072-A1 2-'4-(HYDROXYMETHYL-PHENYLAMINO) -PIPERIDINE-1-YL!-N- (9H-CARBAZOL-3YL) - ACETAMINE DERIVATIVES AND RELATED COMPOUNDS AS NEUROPEPTIDE Y5 (NPY5) LIGANDS FOR THE TREATMENT OF OBESITY LABORATORIOS DEL DR. ESTEVE S.A (ES) 2010-11-04 US disclosed
WO-2010060730-A1 HAIR COLOURING METHOD COMPRISING AFTERTREATMENT HENKEL AG & CO. KGAA (DE) 2010-06-03 WO disclosed
WO-2010022996-A1 CATIONIC ACETYLPYRIDINIUM DERIVATIVES FOR USE AS BLEACH ACTIVATORS HENKEL AG & CO. KGAA (DE) 2010-03-04 WO disclosed
EP-1651220-B1 2-[4- (2-HYDROXYMETHYL-PHENYLAMINO)-PIPERIDIN-1-YL] - N-(9H-CARBAZOL-3-YL) - ACETAMIDE DERIVATIVES AND RELATED COMPOUNDS AS NEUROPEPTIDE Y5 (NPY5) LIGANDS FOR THE TREATMENT OF OBESITY ESTEVE LABOR DR (ES) 2006-12-20 EP disclosed
CN-1829516-A S 2-'4(phenylamino)-piperidin-1-yl!-n-phenyl-acetamine derivatives and related compounds as neuropeptide y5 (npy5) ligands for the treatement of obesity ESTEVE LABOR DR (ES) 2006-09-06 CN disclosed
WO-2006087019-A1 AGENTS FOR COLOURING KERATIN CONTAINING FIBRES HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) 2006-08-24 WO disclosed
EP-1651220-A1 2-[4- (2-HYDROXYMETHYL-PHENYLAMINO)-PIPERIDIN-1-YL] - N-(9H-CARBAZOL-3-YL) - ACETAMIDE DERIVATIVES AND RELATED COMPOUNDS AS NEUROPEPTIDE Y5 (NPY5) LIGANDS FOR THE TREATMENT OF OBESITY LABORATORIOS DEL DR. ESTEVE, S.A. (ES) 2006-05-03 EP disclosed
WO-2006029686-A1 METHOD FOR STYLISHLY CHANGING THE COLOR OF KERATINIC FIBERS HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) 2006-03-23 WO disclosed
CN-1196464-C Novel couplers for oxidative hair dyeing P & G CLAROR INC (US) 2005-04-13 CN disclosed
WO-2005013990-A1 2-`4-(HYDROXYMETHYL-PHENYLAMINO) -PIPERIDINE-1-YL!-N- (9H-CARBAZOL-3-YL) - ACETAMINE DERIVATIVES AND RELATED COMPOUNDS AS NEUROPEPTIDE Y5 (NPY5) LIGANDS FOR THE TREATMENT OF OBESITY LABORATORIOS DEL DR. ESTEVE S.A. (ES) 2005-02-17 WO disclosed
CN-1551756-A Composition for dyeing keratinous fibres comprising a particular dicationic diazo dye �ź㴫 2004-12-01 CN disclosed
CN-1396819-A Novel couplers for oxidative hair dyeing P & G CLAROR INC (US) 2003-02-12 CN disclosed
CN-1334718-A Hair treatment method NOVOZYMES AS (DK) 2002-02-06 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110288086-A1 POLYCYCLIC QUINAZOLINES, PREPARATION THEREOF, AND USE THEREOF AURKA, AURKC, AURKB ALOX15 4805/4885TSHR 4426/4885ALDH1A1 3950/4885
US-20100280072-A1 2-'4-(HYDROXYMETHYL-PHENYLAMINO) -PIPERIDINE-1-YL!-N- (9H-CARBAZOL-3YL) - ACETAMINE DERIVATIVES AND RELATED COMPOUNDS AS NEUROPEPTIDE Y5 (NPY5) LIGANDS FOR THE TREATMENT OF OBESITY NPY5R, NPY4R, NPY2R ALOX15 573/4885TSHR 438/4885ALDH1A1 948/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.