Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.67 |
| ▸ | MEN1 | O00255 | 2/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.67 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.59 |
| ▸ | HTT | P42858 | 5/20 | 0.59 |
| ▸ | LMNA | P02545 | 3/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.59 |
| ▸ | GAA | P10253 | 3/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | LIG1 | P18858 | 2/20 | 0.58 |
| ▸ | LIG3 | P49916 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 4/20 | 0.57 |
| ▸ | RBM39 | Q14498 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12648542 | 0.82 | CFTR (0.72) | MAPTKMT2AMEN1MAPK1KDM4E | |
| SCHEMBL18378408 | 0.82 | CFTR (0.72) | MAPTKMT2AMEN1MAPK1KDM4E | |
| SCHEMBL14082227 | 0.81 | CFTR (0.64) | MAPTKMT2AMEN1MAPK1KDM4E | |
| SCHEMBL684944 | 0.79 | ASF1A (0.74) | MAPTKMT2AMEN1PIK3CGKDM4E | |
| SCHEMBL13401806 | 0.79 | CFTR (0.59) | MAPTKMT2AMEN1MAPK1KDM4E | |
| SCHEMBL14042405 | 0.77 | KDM4E (0.70) | MAPTKMT2AMEN1MAPK1PIK3CG | |
| SCHEMBL14082242 | 0.77 | POLB (0.71) | MAPTKMT2AMEN1MAPK1PIK3CG | |
| SCHEMBL31393968 | 0.76 | KMT2A (0.74) | MAPTKMT2AMEN1MAPK1PIK3CG | |
| SCHEMBL22786752 | 0.75 | KMT2A (0.74) | MAPTKMT2AMEN1KDM4EHTT | |
| SCHEMBL17438105 | 0.75 | KMT2A (0.77) | MAPTKMT2AMEN1MAPK1PIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9771331-B2 | Methods of identifying neuroprotective compounds for retinal ganglion cells | THE JOHNS HOPKINS UNIVERSITY (US) | 2017-09-26 | — | — | US | disclosed |
| US-20090215765-A1 | Neuroprotective compounds for treating optic neuropathies | THE JOHNS HOPKINS UNIVERSITY (US) | 2009-08-27 | — | — | US | disclosed |
| US-20090215765-A1 | Neuroprotective compounds for treating optic neuropathies | THE JOHNS HOPKINS UNIVERSITY (US) | 2009-08-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090215765-A1 | Neuroprotective compounds for treating optic neuropathies | NLN, GAP43, AIFM1 | MAPT 561/4885KMT2A 4656/4885MEN1 3432/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.