Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | ATR | Q13535 | 16/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3663899 | 0.89 | MCL1 (0.38) | ATR | |
| SCHEMBL3721115 | 0.87 | GAA (0.38) | ATR | |
| SCHEMBL13745245 | 0.87 | RAB9A (0.36) | HDAC3HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL3721919 | 0.84 | TYK2 (0.41) | ATR | |
| SCHEMBL3729986 | 0.83 | TYK2 (0.44) | ATR | |
| SCHEMBL3726335 | 0.82 | ATR (0.35) | ATR | |
| SCHEMBL3720955 | 0.81 | TYK2 (0.38) | ATR | |
| SCHEMBL13745067 | 0.81 | TYK2 (0.34) | ATR | |
| SCHEMBL3722959 | 0.80 | TYK2 (0.33) | ATR | |
| SCHEMBL3774212 | 0.80 | ATR (0.38) | ATR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009100375-A1 | SUBSTITUTED IMIDAZOPYRIDAZINES USEFUL AS KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-08-13 | — | — | WO | disclosed |