Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.37 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.35 |
| ▸ | RET | P07949 | 1/20 | 0.34 |
| ▸ | PIM1 | P11309 | 1/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.34 |
| ▸ | FLT1 | P17948 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | FLT3 | P36888 | 1/20 | 0.34 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.34 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.34 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
| ▸ | LTK | P29376 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24718552 | 0.78 | BRD4 (0.56) | BRD4ADORA3ADORA2AADORA2BADORA1 | |
| SCHEMBL13746159 | 0.75 | BRD4 (0.37) | BRD4ADORA3ADORA2AADORA2BADORA1 | |
| SCHEMBL4296651 | 0.75 | KDM4E (0.60) | BRD4ADORA3ADORA2AADORA2BADORA1 | |
| SCHEMBL1187755 | 0.75 | KDM4E (0.64) | BRD4ADORA3ADORA2AADORA2BADORA1 | |
| Bromide SCHEMBL1188167 | 0.73 | KDM4E (0.62) | BRD4ADORA3ADORA2AADORA2BADORA1 | |
| SCHEMBL13248522 | 0.71 | POLB (0.44) | BRD4ADORA3ADORA2AADORA2BADORA1 | |
| SCHEMBL12878973 | 0.71 | KDM4E (0.38) | BRD4ADORA3ADORA2AADORA2BADORA1 | |
| SCHEMBL1188236 | 0.71 | PDE10A (0.35) | BRD4ADORA3ADORA2AADORA2BADORA1 | |
| SCHEMBL14205547 | 0.71 | LMNA (0.53) | KDM4EALDH1A1SMN1; SMN2MALT1MEN1 | |
| SCHEMBL1187561 | 0.67 | SMN1; SMN2 (0.64) | KDM4EALDH1A1SMN1; SMN2PIM1CLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009097970-A1 | TRIAZOLOPYRIDAZINES AS PAR1 INHIBITORS, PRODUCTION THEREOF, AND USE AS MEDICAMENTS | SANOFI-AVENTIS (FR) | 2009-08-13 | — | — | WO | disclosed |
| WO-2009097971-A1 | TRIAZOLIUM SALTS AS PAR1 INHIBITORS, PRODUCTION THEREOF, AND USE AS MEDICAMENTS | SANOFI-AVENTIS (FR) | 2009-08-13 | — | — | WO | disclosed |