Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | GBA1 | P04062 | 2/20 | 0.38 |
| ▸ | FLT3 | P36888 | 1/20 | 0.36 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.36 |
| ▸ | MERTK | Q12866 | 1/20 | 0.36 |
| ▸ | GAS6 | Q14393 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3401749 | 1.00 | ALDH1A1 (0.51) | ALDH1A1SIGMAR1LMNAMAPTGBA1 | |
| SCHEMBL14188698 | 0.86 | SIGMAR1 (0.51) | ALDH1A1SIGMAR1LMNAMAPTGBA1 | |
| SCHEMBL10504025 | 0.86 | SIGMAR1 (0.51) | ALDH1A1SIGMAR1MAPTFLT3TYRO3 | |
| SCHEMBL15292046 | 0.84 | SIGMAR1 (0.50) | ALDH1A1SIGMAR1MAPTFLT3TYRO3 | |
| SCHEMBL3165725 | 0.84 | SIGMAR1 (0.56) | ALDH1A1SIGMAR1MAPT | |
| SCHEMBL15080728 | 0.84 | SIGMAR1 (0.50) | ALDH1A1SIGMAR1MAPTFLT3TYRO3 | |
| SCHEMBL5058871 | 0.84 | SIGMAR1 (0.56) | ALDH1A1SIGMAR1MAPT | |
| SCHEMBL14401346 | 0.84 | SIGMAR1 (0.56) | ALDH1A1SIGMAR1MAPT | |
| SCHEMBL4678046 | 0.84 | SIGMAR1 (0.56) | ALDH1A1SIGMAR1MAPT | |
| SCHEMBL5060895 | 0.84 | SIGMAR1 (0.56) | ALDH1A1SIGMAR1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009098236-A1 | PYRROLO [2, 3-D] PYRIDINES AND USE THEREOF AS TYROSINE KINASE INHIBITORS | NOVARTIS AG (CH) | 2009-08-13 | — | — | WO | disclosed |