Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TUBB1 | Q9H4B7 | 15/20 | 0.62 |
| ▸ | TUBB4A | P04350 | 6/20 | 0.62 |
| ▸ | TUBB | P07437 | 6/20 | 0.62 |
| ▸ | TUBA3C | P0DPH7 | 6/20 | 0.62 |
| ▸ | TUBA1B | P68363 | 6/20 | 0.62 |
| ▸ | TUBA4A | P68366 | 6/20 | 0.62 |
| ▸ | TUBB4B | P68371 | 6/20 | 0.62 |
| ▸ | TUBB3 | Q13509 | 6/20 | 0.62 |
| ▸ | TUBB2A | Q13885 | 6/20 | 0.62 |
| ▸ | TUBB8 | Q3ZCM7 | 6/20 | 0.62 |
| ▸ | TUBA3E | Q6PEY2 | 6/20 | 0.62 |
| ▸ | TUBA1A | Q71U36 | 6/20 | 0.62 |
| ▸ | TUBA1C | Q9BQE3 | 6/20 | 0.62 |
| ▸ | TUBB6 | Q9BUF5 | 6/20 | 0.62 |
| ▸ | TUBB2B | Q9BVA1 | 6/20 | 0.62 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.62 |
| ▸ | SLCO2B1 | O94956 | 1/20 | 0.62 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.62 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.62 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL91388 | 0.92 | TUBB1 (0.76) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL14964022 | 0.90 | MMP2 (0.62) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL786868 | 0.86 | TUBB1 (0.52) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL13952732 | 0.82 | TUBB1 (0.65) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL14192136 | 0.82 | TUBB1 (0.74) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL20105073 | 0.81 | TUBB1 (0.76) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL17145762 | 0.79 | TUBB1 (0.49) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL14191902 | 0.78 | TUBB1 (0.49) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL15489591 | 0.78 | TUBB1 (0.59) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL13774611 | 0.78 | TUBB1 (0.53) | TUBB1TUBB4ATUBBTUBA3CTUBA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7572778-B2 | recognize and bind the tubulin site: antitubulin; useful for treating pathological states which arise from or are exacerbated by cell proliferation as anticancer and/or antiangiogenic activity | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2009-08-11 | — | — | US | disclosed |