Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.50 |
| ▸ | HTR6 | P50406 | 3/20 | 0.46 |
| ▸ | SCARB1 | Q8WTV0 | 11/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.41 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.41 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | HRH2 | P25021 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | HRH1 | P35367 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13747535 | 0.84 | SCARB1 (0.63) | HTR6SCARB1CHRM2HTR1ACHRM5 | |
| SCHEMBL13747174 | 0.84 | SCARB1 (0.63) | HTR6SCARB1CHRM2HTR1ACHRM5 | |
| SCHEMBL4030106 | 0.81 | SCARB1 (0.61) | SCARB1KDM4E | |
| SCHEMBL15899530 | 0.78 | HTR6 (0.55) | HTR6SCARB1CHRM2HTR1ACHRM5 | |
| SCHEMBL10738401 | 0.77 | HTR6 (0.70) | HTR6SCARB1CHRM2HTR1ACHRM5 | |
| SCHEMBL15899412 | 0.75 | HTR6 (0.57) | HTR6SCARB1KDM4EMAPK1TDP1 | |
| SCHEMBL13746724 | 0.74 | KDM4E (0.37) | SIGMAR1HTR6SCARB1CHRM2HTR1A | |
| SCHEMBL13746725 | 0.73 | KDM4E (0.40) | SIGMAR1HTR6CHRM2HTR1ACHRM5 | |
| SCHEMBL15899271 | 0.72 | HTR6 (0.54) | HTR6KDM4EMAPK1TDP1L3MBTL1 | |
| SCHEMBL4205318 | 0.72 | SCARB1 (0.73) | HTR6SCARB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009103022-A1 | DERIVATIVES OF SUBSTITUTED FUSED RING CYCLOINDOLES AND METHODS OF THEIR USE | ITHERX PHARMACEUTICALS, INC. (US) | 2009-08-20 | — | — | WO | disclosed |