Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | EBP | Q15125 | 1/20 | 0.35 |
| ▸ | CYP2A13 | Q16696 | 1/20 | 0.35 |
| ▸ | ACLY | P53396 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 2/20 | 0.34 |
| ▸ | HTR2A | P28223 | 2/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.34 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.34 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.34 |
| ▸ | DRD4 | P21917 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13746724 | 0.81 | KDM4E (0.37) | KDM4EALDH1A1HTTSIGMAR1LMNA | |
| SCHEMBL13747177 | 0.78 | HTR6 (0.45) | KDM4ETDP1KMT2AALDH1A1SIGMAR1 | |
| SCHEMBL13747092 | 0.73 | SIGMAR1 (0.50) | KDM4ETDP1SIGMAR1DRD2HTR2A | |
| SCHEMBL4204074 | 0.73 | ALDH1A1 (0.45) | KDM4ETDP1KMT2AALDH1A1HTT | |
| SCHEMBL13747174 | 0.71 | SCARB1 (0.63) | KDM4ETDP1DRD2HTR2ACHRM2 | |
| SCHEMBL13747535 | 0.71 | SCARB1 (0.63) | KDM4ETDP1DRD2HTR2ACHRM2 | |
| SCHEMBL4030106 | 0.68 | SCARB1 (0.61) | KDM4EKMT2AALDH1A1HTTMEN1 | |
| SCHEMBL11165673 | 0.64 | SIGMAR1 (0.70) | KDM4EKMT2AALDH1A1HTTSIGMAR1 | |
| SCHEMBL11161450 | 0.63 | SIGMAR1 (0.51) | KDM4EKMT2AALDH1A1HTTSIGMAR1 | |
| SCHEMBL13305300 | 0.62 | SIGMAR1 (0.67) | KDM4ETDP1KMT2AALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009103022-A1 | DERIVATIVES OF SUBSTITUTED FUSED RING CYCLOINDOLES AND METHODS OF THEIR USE | ITHERX PHARMACEUTICALS, INC. (US) | 2009-08-20 | — | — | WO | disclosed |