Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCARB1 | Q8WTV0 | 4/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.50 |
| ▸ | HPGD | P15428 | 5/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | KRAS | P01116 | 1/20 | 0.39 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4030106 | 0.87 | SCARB1 (0.61) | SCARB1ALDH1A1KDM4EHSD17B10MEN1 | |
| SCHEMBL13746912 | 0.83 | SCARB1 (0.50) | SCARB1ALDH1A1KDM4EHPGDMEN1 | |
| SCHEMBL13746786 | 0.82 | SCARB1 (0.50) | SCARB1ALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL4027183 | 0.77 | SCARB1 (0.70) | SCARB1ALDH1A1KDM4EHSD17B10TSHR | |
| SCHEMBL13746919 | 0.76 | SCARB1 (0.57) | SCARB1ALDH1A1KDM4EHSD17B10MEN1 | |
| SCHEMBL13746921 | 0.73 | SCARB1 (0.50) | SCARB1ALDH1A1KDM4EHPGDMEN1 | |
| SCHEMBL13746624 | 0.73 | SCARB1 (0.60) | SCARB1KDM4EHSD17B10KMT2ANPC1 | |
| SCHEMBL4030252 | 0.70 | SCARB1 (0.70) | SCARB1ALDH1A1KDM4EHSD17B10NPC1 | |
| SCHEMBL4030140 | 0.70 | SCARB1 (0.59) | SCARB1ALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL4028758 | 0.70 | SCARB1 (0.72) | SCARB1HSD17B10NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009103022-A1 | DERIVATIVES OF SUBSTITUTED FUSED RING CYCLOINDOLES AND METHODS OF THEIR USE | ITHERX PHARMACEUTICALS, INC. (US) | 2009-08-20 | — | — | WO | disclosed |