Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCARB1 | Q8WTV0 | 5/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.40 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.40 |
| ▸ | FLT1 | P17948 | 2/20 | 0.40 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.40 |
| ▸ | KDR | P35968 | 2/20 | 0.40 |
| ▸ | RORC | P51449 | 2/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4027183 | 0.81 | SCARB1 (0.70) | SCARB1HSD17B10ALDH1A1RORCPTGDR2 | |
| SCHEMBL4030252 | 0.81 | SCARB1 (0.70) | SCARB1HSD17B10NPC1ALDH1A1RORC | |
| SCHEMBL13746624 | 0.81 | SCARB1 (0.60) | SCARB1HSD17B10NPC1RORCPTGDR2 | |
| SCHEMBL13747418 | 0.81 | SCARB1 (0.53) | SCARB1HSD17B10NPC1ALDH1A1RORC | |
| SCHEMBL4030106 | 0.80 | SCARB1 (0.61) | SCARB1HSD17B10NPC1ALDH1A1RORC | |
| SCHEMBL4189175 | 0.80 | SCARB1 (0.69) | SCARB1HSD17B10NPC1ALDH1A1RORC | |
| SCHEMBL4024931 | 0.80 | SCARB1 (0.69) | SCARB1HSD17B10NPC1ALDH1A1HPGD | |
| SCHEMBL4028758 | 0.80 | SCARB1 (0.72) | SCARB1HSD17B10NPC1RORCPTGDR2 | |
| SCHEMBL4031956 | 0.80 | THRB (0.42) | SCARB1PDGFRBFGFR1PDGFRAFLT1 | |
| SCHEMBL13747173 | 0.80 | SCARB1 (0.58) | SCARB1RORCHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009103022-A1 | DERIVATIVES OF SUBSTITUTED FUSED RING CYCLOINDOLES AND METHODS OF THEIR USE | ITHERX PHARMACEUTICALS, INC. (US) | 2009-08-20 | — | — | WO | disclosed |