Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPBWR1 | P48145 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | CCR1 | P32246 | 1/20 | 0.41 |
| ▸ | PTGDR2 | Q9Y5Y4 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | SLC2A1 | P11166 | 2/20 | 0.39 |
| ▸ | SLC2A3 | P11169 | 2/20 | 0.39 |
| ▸ | SLC2A4 | P14672 | 2/20 | 0.39 |
| ▸ | SLC2A2 | P11168 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.38 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14330480 | 0.87 | NPC1 (0.40) | SMN1; SMN2CCR1PTGDR2MAPTSLC2A1 | |
| SCHEMBL13755154 | 0.84 | NPBWR1 (0.44) | NPBWR1SMN1; SMN2CCR1PTGDR2KDM4E | |
| SCHEMBL16832582 | 0.82 | SLC2A1 (0.49) | NPBWR1SMN1; SMN2CCR1PTGDR2KDM4E | |
| SCHEMBL14331547 | 0.81 | PTGDR2 (0.43) | NPBWR1SMN1; SMN2CCR1PTGDR2KDM4E | |
| SCHEMBL13748686 | 0.81 | NPBWR1 (0.42) | NPBWR1SMN1; SMN2CCR1PTGDR2KDM4E | |
| SCHEMBL16832143 | 0.77 | RAB9A (0.56) | NPBWR1SMN1; SMN2CCR1KDM4EALDH1A1 | |
| SCHEMBL23663113 | 0.73 | NPBWR1 (0.50) | NPBWR1SMN1; SMN2KDM4EALDH1A1MAPT | |
| SCHEMBL22744039 | 0.72 | NPBWR1 (0.46) | NPBWR1SMN1; SMN2KDM4EALDH1A1MAPT | |
| SCHEMBL30915543 | 0.72 | NPBWR1 (0.47) | NPBWR1SMN1; SMN2GAA | |
| SCHEMBL1197409 | 0.70 | KDM4E (0.52) | NPBWR1SMN1; SMN2KDM4EALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090197869-A1 | AZEPINE INHIBITORS OF JANUS KINASES | INCYTE CORPORATION, A DELAWARE CORPORATION | 2009-08-06 | — | — | US | disclosed |
| US-20070149506-A1 | Azepine inhibitors of Janus kinases | INCYTE CORPORATION | 2007-06-28 | — | — | US | disclosed |
| US-20070149506-A1 | Azepine inhibitors of Janus kinases | INCYTE CORPORATION | 2007-06-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090197869-A1 | AZEPINE INHIBITORS OF JANUS KINASES | JAK1, JAK3, JAK2 | NPBWR1 2202/4885SMN1; SMN2 3556/4885CCR1 1334/4885 |
| US-20070149506-A1 | Azepine inhibitors of Janus kinases | JAK1, JAK3, JAK2 | NPBWR1 2202/4885SMN1; SMN2 3556/4885CCR1 1334/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.