Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMB5 | P28074 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
| ▸ | PPARA | Q07869 | 1/20 | 0.34 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.34 |
| ▸ | SOAT1 | P35610 | 3/20 | 0.33 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.33 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.33 |
| ▸ | GCGR | P47871 | 1/20 | 0.33 |
| ▸ | BID | P55957 | 2/20 | 0.33 |
| ▸ | BCL2L1 | Q07817 | 2/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.33 |
| ▸ | BAK1 | Q16611 | 2/20 | 0.33 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1840982 | 0.97 | HSD11B1 (0.38) | PSMB5HSD11B1DPP4PPARALIPG | |
| SCHEMBL8838466 | 0.90 | DPP4 (0.37) | PSMB5DPP4PPARAADORA3ADORA1 | |
| SCHEMBL1370515 | 0.87 | PSMB5 (0.38) | PSMB5HSD11B1PPARALIPGSOAT1 | |
| SCHEMBL11045794 | 0.85 | NR1H2 (0.39) | PPARALIPGTLR8NR1H3 | |
| SCHEMBL10744231 | 0.83 | DPP4 (0.35) | DPP4 | |
| SCHEMBL1900101 | 0.83 | PDCD1 (0.34) | PSMB5HSD11B1PPARALIPGGCGR | |
| SCHEMBL5685480 | 0.82 | DPP4 (0.39) | DPP4PPARA | |
| SCHEMBL27582158 | 0.79 | TDP1 (0.38) | DPP4 | |
| SCHEMBL1897418 | 0.79 | PSMB5 (0.44) | PSMB5HSD11B1TLR8 | |
| SCHEMBL367335 | 0.78 | DPP4 (0.52) | PSMB5HSD11B1DPP4PPARALIPG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4745971-B2 | — | — | 2011-08-10 | — | — | JP | claimed |
| EP-1696907-A4 | PDK-1/AKT SIGNALING INHIBITORS | UNIV OHIO STATE RES FOUND (US) | 2007-09-05 | — | — | EP | claimed |
| EP-1696907-A1 | PDK-1/AKT SIGNALING INHIBITORS | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2006-09-06 | — | — | EP | claimed |
| WO-2005044130-A1 | PDK-1/AKT SIGNALING INHIBITORS | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2005-05-19 | — | — | WO | claimed |
| WO-2005044130-A9 | PDK-1/AKT SIGNALING INHIBITORS | UNIV OHIO STATE RES FOUND (US) | 2005-09-15 | — | — | WO | disclosed |
| EP-1133475-A1 | SUBSTITUTED BENZO DE]ISOQUINOLINE-1,3-DIONES | MERCK PATENT GmbH (DE) | 2001-09-19 | — | — | EP | disclosed |
| WO-2000031039-A1 | SUBSTITUTED BENZO[DE]ISOQUINOLINE-1,3-DIONES | MERCK PATENT GMBH (DE) | 2000-06-02 | — | — | WO | disclosed |