Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11206485 | 0.72 | POLB (0.37) | POLBKDM4EKMT2AALDH1A1MAPK1 | |
| SCHEMBL19249449 | 0.72 | POLB (0.37) | POLBKDM4EKMT2AALDH1A1MAPK1 | |
| SCHEMBL254096 | 0.72 | KMT2A (0.40) | POLBKDM4EKMT2AALDH1A1MAPK1 | |
| SCHEMBL2236435 | 0.71 | — | — | |
| SCHEMBL1809810 | 0.71 | L3MBTL1 (0.32) | POLBKDM4EKMT2AALDH1A1LMNA | |
| SCHEMBL3227390 | 0.69 | HRH3 (0.43) | POLBKDM4EKMT2AALDH1A1MAPK1 | |
| SCHEMBL10574287 | 0.67 | SIGMAR1 (0.36) | POLBKDM4EKMT2AALDH1A1MAPK1 | |
| SCHEMBL5665559 | 0.67 | — | — | |
| SCHEMBL24911028 | 0.67 | POLB (0.38) | POLBKDM4EKMT2AALDH1A1MAPK1 | |
| SCHEMBL12706319 | 0.67 | POLB (0.40) | POLBKDM4EKMT2AALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7601856-B2 | Benzofurans as potassium ion channel modulators | WYETH (US) | 2009-10-13 | — | — | US | claimed |
| US-20080027049-A1 | Such as 2,2-Dimethyl-N-(6,7,8,9-tetrahydro-dibenzofuran-2-yl)-propionamide | WYETH (US) | 2008-01-31 | — | — | US | claimed |
| US-8791102-B2 | Acetanilide sphingosine-1-phosphate receptor antagonists | EXELIXIS, INC. (US) | 2014-07-29 | — | — | US | disclosed |
| US-20110288076-A1 | Sphingosine-1-Phosphate Receptor Antagonists | EXELIXIS, INC. (US) | 2011-11-24 | — | — | US | disclosed |
| US-7601856-B2 | Benzofurans as potassium ion channel modulators | WYETH (US) | 2009-10-13 | — | — | US | disclosed |
| US-20080027049-A1 | Such as 2,2-Dimethyl-N-(6,7,8,9-tetrahydro-dibenzofuran-2-yl)-propionamide | WYETH (US) | 2008-01-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080027049-A1 | Such as 2,2-Dimethyl-N-(6,7,8,9-tetrahydro-dibenzofuran-2-yl)-propionamide | KCNJ2, KCNJ5, KCNA5 | POLB 4205/4885KDM4E 262/4885KMT2A 525/4885 |
| US-20110288076-A1 | Sphingosine-1-Phosphate Receptor Antagonists | S1PR1, S1PR2, S1PR3 | POLB 2626/4885KDM4E 2688/4885KMT2A 3292/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.