Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACSS2 | Q9NR19 | 2/20 | 0.33 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.33 |
| ▸ | KIT | P10721 | 1/20 | 0.32 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.31 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.31 |
| ▸ | CDK2 | P24941 | 1/20 | 0.31 |
| ▸ | GSK3B | P49841 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13748615 | 0.92 | LRRK2 (0.37) | ACSS2MAPK1LRRK2 | |
| SCHEMBL13749233 | 0.89 | MAPK1 (0.33) | KITMAPK1 | |
| SCHEMBL2274094 | 0.84 | CNR1 (0.36) | ACSS2KITPTGER1NTRK1MAPK1 | |
| SCHEMBL2276520 | 0.80 | L3MBTL1 (0.47) | — | |
| SCHEMBL17146107 | 0.75 | MAPK1 (0.33) | KITMAPK1LRRK2 | |
| SCHEMBL12374202 | 0.74 | MAPK1 (0.41) | MAPK1 | |
| SCHEMBL2277546 | 0.74 | MAPK1 (0.41) | MAPK1 | |
| SCHEMBL17430340 | 0.74 | TTK (0.41) | ACSS2PTGER1NTRK1 | |
| SCHEMBL2280858 | 0.73 | CNR1 (0.35) | KITPTGER1MAPK1LRRK2 | |
| SCHEMBL30084146 | 0.71 | PTGER1 (0.41) | PTGER1NTRK1LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009105500-A1 | COMPOUNDS THAT ARE ERK INHIBITORS | SCHERING CORPORATION (US) | 2009-08-27 | — | — | WO | disclosed |