Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.37 |
| ▸ | WNT3A | P56704 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | ATR | Q13535 | 1/20 | 0.33 |
| ▸ | MET | P08581 | 2/20 | 0.32 |
| ▸ | BUB1 | O43683 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.32 |
| ▸ | ACSS2 | Q9NR19 | 1/20 | 0.32 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.31 |
| ▸ | SLC13A5 | Q86YT5 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13748972 | 0.92 | ACSS2 (0.33) | LRRK2MAPK1ACSS2 | |
| SCHEMBL13749233 | 0.90 | MAPK1 (0.33) | MAPK1 | |
| SCHEMBL2280858 | 0.82 | CNR1 (0.35) | LRRK2MAPK1CNR1ATRDYRK1A | |
| SCHEMBL2276443 | 0.78 | L3MBTL1 (0.49) | CNR1MAPT | |
| SCHEMBL31021936 | 0.77 | MAPK1 (0.34) | LRRK2MAPK1BUB1DYRK1AROCK2 | |
| SCHEMBL17146107 | 0.75 | MAPK1 (0.33) | LRRK2MAPK1MAPT | |
| SCHEMBL2274094 | 0.75 | CNR1 (0.36) | MAPK1CNR1MAPTACSS2 | |
| SCHEMBL12374195 | 0.73 | JAK2 (0.37) | MAPK1METBUB1DGAT2 | |
| SCHEMBL2273869 | 0.73 | JAK2 (0.37) | MAPK1METBUB1DGAT2 | |
| SCHEMBL30084146 | 0.72 | PTGER1 (0.41) | LRRK2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009105500-A1 | COMPOUNDS THAT ARE ERK INHIBITORS | SCHERING CORPORATION (US) | 2009-08-27 | — | — | WO | disclosed |