Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 17/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 14/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 10/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 14/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 7/20 | 0.55 |
| ▸ | CASP1 | P29466 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | USP2 | O75604 | 4/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6378751 | 0.84 | CYP2D6 (0.57) | CYP3A4CYP2D6ALDH1A1GAATSHR | |
| SCHEMBL1427267 | 0.82 | TNIK (0.47) | CYP2D6ALDH1A1KDM4ETSHRSMN1; SMN2 | |
| SCHEMBL13741668 | 0.81 | CYP3A4 (0.54) | CYP3A4CYP2D6CYP2C19ALDH1A1CYP2C9 | |
| SCHEMBL19613477 | 0.78 | OPRL1 (0.58) | CYP3A4CYP2D6KDM4EGAATSHR | |
| SCHEMBL951796 | 0.78 | OPRL1 (0.58) | CYP3A4CYP2D6KDM4EGAATSHR | |
| Hydrochloric Acid SCHEMBL6615899 | 0.76 | POLB (0.59) | CYP3A4CYP2D6KDM4EGAATSHR | |
| SCHEMBL30889332 | 0.76 | CYP2D6 (0.54) | CYP3A4CYP2D6ALDH1A1TSHRUSP2 | |
| SCHEMBL30278409 | 0.76 | CYP2D6 (0.54) | CYP3A4CYP2D6ALDH1A1TSHRUSP2 | |
| SCHEMBL30278414 | 0.76 | CYP2D6 (0.54) | CYP3A4CYP2D6ALDH1A1TSHRUSP2 | |
| SCHEMBL25153605 | 0.75 | LPL (0.44) | CYP3A4CYP2D6CYP2C19ALDH1A1CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090215766-A1 | TETRACYCLIC INHIBITORS OF JANUS KINASES | INCYTE CORPORATION | 2009-08-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090215766-A1 | TETRACYCLIC INHIBITORS OF JANUS KINASES | JAK1, JAK2, JAK3 | CYP3A4 3493/4885CYP2D6 3376/4885CYP2C19 3165/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.